Chloride ion
Star0
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Chloride ion
- DrugBank Accession Number
- DB14547
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 35.453
Monoisotopic: 34.968852707 - Chemical Formula
- Cl
- Synonyms
- Chloride
- Chloride (ion)
- Chloride ions
- Chloride(1-)
- Chlorine anion
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism ALanosterol 14-alpha demethylase modulatorYeast - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image PERIOLIMEL N4-600E İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 1000 ML Chloride ion (24 mmol) + Acetate (27 mmol) + Alanine (3.66 g) + Arginine (2.48 g) + Aspartic acid (0.73 g) + Calcium (2 mmol) + Calcium chloride dihydrate (0.3 g) + D-glucose (75 g) + Glutamic acid (1.26 g) + Glycine (1.76 g) + Histidine (1.51 g) + Isoleucine (1.26 g) + Leucine (1.76 g) + Lysine (1.99 g) + Magnesium (2.2 mmol) + Magnesium chloride hexahydrate (0.45 g) + Methionine (1.26 g) + Olive oil (6 g) + Phenylalanine (1.76 g) + Phosphate ion (8.5 mmol) + Potassium (16 mmol) + Potassium chloride (1.19 g) + Proline (1.51 g) + Serine (1 g) + Sodium acetate trihydrate (1.16 g) + Sodium cation (21 mmol) + Sodium glycerophosphate hydrate (1.91 g) + Soybean oil (6 g) + Threonine (1.26 g) + Tryptophan (0.42 g) + Tyrosine (0.06 g) + Valine (1.62 g) Injection, emulsion Intravenous EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş. 2020-08-14 Not applicable Turkey PERIOLIMEL N4-600E İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 1500 ML Chloride ion (37 mmol) + Acetate (41 mmol) + Alanine (5.5 g) + Arginine (3.72 g) + Aspartic acid (1.1 g) + Calcium (3 mmol) + Calcium chloride dihydrate (0.44 g) + D-glucose (112.5 g) + Glutamic acid (1.9 g) + Glycine (2.63 g) + Histidine (2.26 g) + Isoleucine (1.9 g) + Leucine (2.63 g) + Lysine (2.99 g) + Magnesium (3.3 mmol) + Magnesium chloride hexahydrate (0.67 g) + Methionine (1.9 g) + Olive oil (9 g) + Phenylalanine (2.63 g) + Phosphate ion (12.7 mmol) + Potassium (24 mmol) + Potassium chloride (1.79 g) + Proline (2.26 g) + Serine (1.5 g) + Sodium acetate trihydrate (1.73 g) + Sodium cation (31.5 mmol) + Sodium glycerophosphate hydrate (2.87 g) + Soybean oil (9 g) + Threonine (1.9 g) + Tryptophan (0.64 g) + Tyrosine (0.1 g) + Valine (2.43 g) Injection, emulsion Intravenous EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş. 2020-08-14 Not applicable Turkey PERIOLIMEL N4-600E İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 2000 ML Chloride ion (49 mmol) + Acetate (55 mmol) + Alanine (7.33 g) + Arginine (4.96 g) + Aspartic acid (1.46 g) + Calcium (4 mmol) + Calcium chloride dihydrate (0.59 g) + D-glucose (150 g) + Glutamic acid (2.53 g) + Glycine (3.51 g) + Histidine (3.02 g) + Isoleucine (2.53 g) + Leucine (3.51 g) + Lysine (3.98 g) + Magnesium (4.4 mmol) + Magnesium chloride hexahydrate (0.9 g) + Methionine (2.53 g) + Olive oil (12 g) + Phenylalanine (3.51 g) + Phosphate ion (17 mmol) + Potassium (32 mmol) + Potassium chloride (2.38 g) + Proline (3.02 g) + Serine (2 g) + Sodium acetate trihydrate (2.31 g) + Sodium cation (42 mmol) + Sodium glycerophosphate hydrate (3.82 g) + Soybean oil (12 g) + Threonine (2.53 g) + Tryptophan (0.85 g) + Tyrosine (0.13 g) + Valine (3.24 g) Injection, emulsion Intravenous EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş. 2020-08-14 Not applicable Turkey PERIOLIMEL N4-600E İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 2500 ML Chloride ion (61 mmol) + Acetate (69 mmol) + Alanine (9.16 g) + Arginine (6.2 g) + Aspartic acid (1.83 g) + Calcium (5 mmol) + Calcium chloride dihydrate (0.74 g) + D-glucose (187.5 g) + Glutamic acid (3.16 g) + Glycine (4.39 g) + Histidine (3.77 g) + Isoleucine (3.16 g) + Leucine (4.39 g) + Lysine (4.98 g) + Magnesium (5.5 mmol) + Magnesium chloride hexahydrate (1.12 g) + Methionine (3.16 g) + Olive oil (15 g) + Phenylalanine (4.39 g) + Phosphate ion (21.2 mmol) + Potassium (40 mmol) + Potassium chloride (2.98 g) + Proline (3.77 g) + Serine (2.5 g) + Sodium acetate trihydrate (2.89 g) + Sodium cation (52.5 mmol) + Sodium glycerophosphate hydrate (4.78 g) + Soybean oil (15 g) + Threonine (3.16 g) + Tryptophan (1.06 g) + Tyrosine (0.16 g) + Valine (4.05 g) Injection, emulsion Intravenous EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş. 2020-08-14 Not applicable Turkey POLİFLEKS LAKTATLI RİNGER IV İNFÜZYON İÇİN ÇÖZELTİ, 100 ML (PVC TORBA) SETLI Chloride ion (112 mEq/L) + Calcium cation (4 mEq/L) + Lactic acid (26.77 mEq/L) + Potassium cation (5.37 mEq/L) + Sodium cation (129.3 mEq/L) Solution Intravenous POLİFARMA İLAÇ SAN. VE TİC. A.Ş. 2005-02-21 Not applicable Turkey - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Rurina Chloride ion (0.11 g/1L) + Potassium cation (0.25 g/1L) + Sulfate ion (3.6 g/1L) Liquid Topical TELOM-X GENE Co., Ltd. 2017-07-01 Not applicable US Rurina Chloride ion (0.11 g/1L) + Potassium cation (0.25 g/1L) + Sulfate ion (3.6 g/1L) Liquid Topical Nano Bio Tech Co.,Ltd 2017-07-01 Not applicable US Telom-X-gene Chloride ion (0.11 g/1L) + Potassium cation (0.25 g/1L) + Sulfate ion (3.6 g/1L) Liquid Topical TELOM-X GENE Co., Ltd. 2017-07-01 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as homogeneous halogens. These are inorganic non-metallic compounds in which the largest atom is a nobel gas.
- Kingdom
- Inorganic compounds
- Super Class
- Homogeneous non-metal compounds
- Class
- Homogeneous halogens
- Sub Class
- Not Available
- Direct Parent
- Homogeneous halogens
- Alternative Parents
- Not Available
- Substituents
- Homogeneous halogen
- Molecular Framework
- Not Available
- External Descriptors
- halide anion, monoatomic chlorine (CHEBI:17996) / an anion (CL-)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Q32ZN48698
- CAS number
- 16887-00-6
- InChI Key
- VEXZGXHMUGYJMC-UHFFFAOYSA-M
- InChI
- InChI=1S/ClH/h1H/p-1
- IUPAC Name
- chloride
- SMILES
- [Cl-]
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0000492
- KEGG Compound
- C00698
- ChemSpider
- 306
- BindingDB
- 26979
- 153974
- ChEBI
- 17996
- ChEMBL
- CHEMBL19429
- PDBe Ligand
- CL
- Wikipedia
- Chloride
- PDB Entries
- 102l / 103l / 107l / 108l / 109l / 110l / 111l / 112l / 113l / 114l … show 18359 more
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Completed Not Available Nasal Obstruction 1 somestatus stop reason just information to hide Not Available Completed Basic Science Pruritus 1 somestatus stop reason just information to hide Not Available Completed Supportive Care Postoperative pain 1 somestatus stop reason just information to hide Not Available Recruiting Not Available Cardiotoxicity / Evaluation Studies / Reactions Adverse 1 somestatus stop reason just information to hide Not Available Recruiting Screening Stage IB Non-Small Cell Lung Carcinoma AJCC v7 / Stage II Non-Small Cell Lung Cancer AJCC v7 / Stage IIA Lung Cancer AJCC v8 / Stage IIB Lung Cancer AJCC v8 / Stage IIIA Lung Cancer AJCC v8 / Stage IIIA Non-Small Cell Lung Cancer AJCC v7 / Stage IIIB Lung Cancer AJCC v8 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, film coated Oral Capsule Oral Injection, emulsion Intravenous Solution Intravenous 100.000 mL Solution Intravenous 50.000 mL Liquid Topical Solution Intravenous - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 0.61 Chemaxon pKa (Strongest Acidic) -7 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 5.62 m3·mol-1 Chemaxon Polarizability 2.39 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 110.8201 predictedDeepCCS 1.0 (2019) [M+H]+ 112.575516 predictedDeepCCS 1.0 (2019) [M+Na]+ 119.57085 predictedDeepCCS 1.0 (2019)
Targets
Build, predict & validate machine-learning models
Use our structured and evidence-based datasets to unlock newinsights and accelerate drug research.
Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
1. DetailsLanosterol 14-alpha demethylase
- Kind
- Protein
- Organism
- Yeast
- Pharmacological action
- Yes
- Actions
- Modulator
- General Function
- Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (PubMed:10393548, PubMed:28258218, PubMed:8647850, PubMed:9559662). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity). In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity). Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (PubMed:10393548, PubMed:28258218, PubMed:8647850, PubMed:9559662). Can also use substrates not intrinsic to fungi, such as 24,25-dihydrolanosterol (DHL), producing 4,4-dimethyl-8,14-cholestadien-3-beta-ol, but at lower rates than the endogenous substrates (By similarity).
- Specific Function
- heme binding
- Gene Name
- ERG11
- Uniprot ID
- P10613
- Uniprot Name
- Lanosterol 14-alpha demethylase
- Molecular Weight
- 60674.965 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
Drug created at July 12, 2018 21:42 / Updated at August 26, 2024 19:23