Chloride ion

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Chloride ion
DrugBank Accession Number
DB14547
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 35.453
Monoisotopic: 34.968852707
Chemical Formula
Cl
Synonyms
  • Chloride
  • Chloride (ion)
  • Chloride ions
  • Chloride(1-)
  • Chlorine anion

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
ALanosterol 14-alpha demethylase
modulator
Yeast
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
PERIOLIMEL N4-600E İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 1000 MLChloride ion (24 mmol) + Acetate (27 mmol) + Alanine (3.66 g) + Arginine (2.48 g) + Aspartic acid (0.73 g) + Calcium (2 mmol) + Calcium chloride dihydrate (0.3 g) + D-glucose (75 g) + Glutamic acid (1.26 g) + Glycine (1.76 g) + Histidine (1.51 g) + Isoleucine (1.26 g) + Leucine (1.76 g) + Lysine (1.99 g) + Magnesium (2.2 mmol) + Magnesium chloride hexahydrate (0.45 g) + Methionine (1.26 g) + Olive oil (6 g) + Phenylalanine (1.76 g) + Phosphate ion (8.5 mmol) + Potassium (16 mmol) + Potassium chloride (1.19 g) + Proline (1.51 g) + Serine (1 g) + Sodium acetate trihydrate (1.16 g) + Sodium cation (21 mmol) + Sodium glycerophosphate hydrate (1.91 g) + Soybean oil (6 g) + Threonine (1.26 g) + Tryptophan (0.42 g) + Tyrosine (0.06 g) + Valine (1.62 g)Injection, emulsionIntravenousEİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.2020-08-14Not applicableTurkey flag
PERIOLIMEL N4-600E İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 1500 MLChloride ion (37 mmol) + Acetate (41 mmol) + Alanine (5.5 g) + Arginine (3.72 g) + Aspartic acid (1.1 g) + Calcium (3 mmol) + Calcium chloride dihydrate (0.44 g) + D-glucose (112.5 g) + Glutamic acid (1.9 g) + Glycine (2.63 g) + Histidine (2.26 g) + Isoleucine (1.9 g) + Leucine (2.63 g) + Lysine (2.99 g) + Magnesium (3.3 mmol) + Magnesium chloride hexahydrate (0.67 g) + Methionine (1.9 g) + Olive oil (9 g) + Phenylalanine (2.63 g) + Phosphate ion (12.7 mmol) + Potassium (24 mmol) + Potassium chloride (1.79 g) + Proline (2.26 g) + Serine (1.5 g) + Sodium acetate trihydrate (1.73 g) + Sodium cation (31.5 mmol) + Sodium glycerophosphate hydrate (2.87 g) + Soybean oil (9 g) + Threonine (1.9 g) + Tryptophan (0.64 g) + Tyrosine (0.1 g) + Valine (2.43 g)Injection, emulsionIntravenousEİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.2020-08-14Not applicableTurkey flag
PERIOLIMEL N4-600E İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 2000 MLChloride ion (49 mmol) + Acetate (55 mmol) + Alanine (7.33 g) + Arginine (4.96 g) + Aspartic acid (1.46 g) + Calcium (4 mmol) + Calcium chloride dihydrate (0.59 g) + D-glucose (150 g) + Glutamic acid (2.53 g) + Glycine (3.51 g) + Histidine (3.02 g) + Isoleucine (2.53 g) + Leucine (3.51 g) + Lysine (3.98 g) + Magnesium (4.4 mmol) + Magnesium chloride hexahydrate (0.9 g) + Methionine (2.53 g) + Olive oil (12 g) + Phenylalanine (3.51 g) + Phosphate ion (17 mmol) + Potassium (32 mmol) + Potassium chloride (2.38 g) + Proline (3.02 g) + Serine (2 g) + Sodium acetate trihydrate (2.31 g) + Sodium cation (42 mmol) + Sodium glycerophosphate hydrate (3.82 g) + Soybean oil (12 g) + Threonine (2.53 g) + Tryptophan (0.85 g) + Tyrosine (0.13 g) + Valine (3.24 g)Injection, emulsionIntravenousEİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.2020-08-14Not applicableTurkey flag
PERIOLIMEL N4-600E İNFÜZYONLUK ELEKTROLİTLİ AMİNOASİT ÇÖZELTİSİ, GLUKOZ ÇÖZELTİSİ VE LİPİD EMÜLSİYONU, 2500 MLChloride ion (61 mmol) + Acetate (69 mmol) + Alanine (9.16 g) + Arginine (6.2 g) + Aspartic acid (1.83 g) + Calcium (5 mmol) + Calcium chloride dihydrate (0.74 g) + D-glucose (187.5 g) + Glutamic acid (3.16 g) + Glycine (4.39 g) + Histidine (3.77 g) + Isoleucine (3.16 g) + Leucine (4.39 g) + Lysine (4.98 g) + Magnesium (5.5 mmol) + Magnesium chloride hexahydrate (1.12 g) + Methionine (3.16 g) + Olive oil (15 g) + Phenylalanine (4.39 g) + Phosphate ion (21.2 mmol) + Potassium (40 mmol) + Potassium chloride (2.98 g) + Proline (3.77 g) + Serine (2.5 g) + Sodium acetate trihydrate (2.89 g) + Sodium cation (52.5 mmol) + Sodium glycerophosphate hydrate (4.78 g) + Soybean oil (15 g) + Threonine (3.16 g) + Tryptophan (1.06 g) + Tyrosine (0.16 g) + Valine (4.05 g)Injection, emulsionIntravenousEİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.2020-08-14Not applicableTurkey flag
POLİFLEKS LAKTATLI RİNGER IV İNFÜZYON İÇİN ÇÖZELTİ, 100 ML (PVC TORBA) SETLIChloride ion (112 mEq/L) + Calcium cation (4 mEq/L) + Lactic acid (26.77 mEq/L) + Potassium cation (5.37 mEq/L) + Sodium cation (129.3 mEq/L)SolutionIntravenousPOLİFARMA İLAÇ SAN. VE TİC. A.Ş.2005-02-21Not applicableTurkey flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
RurinaChloride ion (0.11 g/1L) + Potassium cation (0.25 g/1L) + Sulfate ion (3.6 g/1L)LiquidTopicalTELOM-X GENE Co., Ltd.2017-07-01Not applicableUS flag
RurinaChloride ion (0.11 g/1L) + Potassium cation (0.25 g/1L) + Sulfate ion (3.6 g/1L)LiquidTopicalNano Bio Tech Co.,Ltd2017-07-01Not applicableUS flag
Telom-X-geneChloride ion (0.11 g/1L) + Potassium cation (0.25 g/1L) + Sulfate ion (3.6 g/1L)LiquidTopicalTELOM-X GENE Co., Ltd.2017-07-01Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as homogeneous halogens. These are inorganic non-metallic compounds in which the largest atom is a nobel gas.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Homogeneous halogens
Sub Class
Not Available
Direct Parent
Homogeneous halogens
Alternative Parents
Not Available
Substituents
Homogeneous halogen
Molecular Framework
Not Available
External Descriptors
halide anion, monoatomic chlorine (CHEBI:17996) / an anion (CL-)
Affected organisms
Not Available

Chemical Identifiers

UNII
Q32ZN48698
CAS number
16887-00-6
InChI Key
VEXZGXHMUGYJMC-UHFFFAOYSA-M
InChI
InChI=1S/ClH/h1H/p-1
IUPAC Name
chloride
SMILES
[Cl-]

References

General References
Not Available
Human Metabolome Database
HMDB0000492
KEGG Compound
C00698
ChemSpider
306
BindingDB
26979
RxNav
153974
ChEBI
17996
ChEMBL
CHEMBL19429
PDBe Ligand
CL
Wikipedia
Chloride
PDB Entries
102l / 103l / 107l / 108l / 109l / 110l / 111l / 112l / 113l / 114l
show 18359 more

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
Not AvailableCompletedNot AvailableNasal Obstruction1somestatusstop reasonjust information to hide
Not AvailableCompletedBasic SciencePruritus1somestatusstop reasonjust information to hide
Not AvailableCompletedSupportive CarePostoperative pain1somestatusstop reasonjust information to hide
Not AvailableRecruitingNot AvailableCardiotoxicity / Evaluation Studies / Reactions Adverse1somestatusstop reasonjust information to hide
Not AvailableRecruitingScreeningStage IB Non-Small Cell Lung Carcinoma AJCC v7 / Stage II Non-Small Cell Lung Cancer AJCC v7 / Stage IIA Lung Cancer AJCC v8 / Stage IIB Lung Cancer AJCC v8 / Stage IIIA Lung Cancer AJCC v8 / Stage IIIA Non-Small Cell Lung Cancer AJCC v7 / Stage IIIB Lung Cancer AJCC v81somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, film coatedOral
CapsuleOral
Injection, emulsionIntravenous
SolutionIntravenous100.000 mL
SolutionIntravenous50.000 mL
LiquidTopical
SolutionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.61Chemaxon
pKa (Strongest Acidic)-7Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count0Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area0 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity5.62 m3·mol-1Chemaxon
Polarizability2.39 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-110.8201
predicted
DeepCCS 1.0 (2019)
[M+H]+112.575516
predicted
DeepCCS 1.0 (2019)
[M+Na]+119.57085
predicted
DeepCCS 1.0 (2019)

Targets

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Kind
Protein
Organism
Yeast
Pharmacological action
Yes
Actions
Modulator
General Function
Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (PubMed:10393548, PubMed:28258218, PubMed:8647850, PubMed:9559662). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity). In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity). Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (PubMed:10393548, PubMed:28258218, PubMed:8647850, PubMed:9559662). Can also use substrates not intrinsic to fungi, such as 24,25-dihydrolanosterol (DHL), producing 4,4-dimethyl-8,14-cholestadien-3-beta-ol, but at lower rates than the endogenous substrates (By similarity).
Specific Function
heme binding
Gene Name
ERG11
Uniprot ID
P10613
Uniprot Name
Lanosterol 14-alpha demethylase
Molecular Weight
60674.965 Da
References
  1. Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]

Drug created at July 12, 2018 21:42 / Updated at August 26, 2024 19:23