PF-06459988

DB14768InvestigationalSmall molecule

PF-06459988 is under investigation in clinical trial NCT02297425 (A Study For Patients With EGFRm (Epidermal Growth Factor Receptor Mutant) Lung Cancer).

Mechanism: Pharmacologically active on Epidermal growth factor receptor
Curator reviewed
Formula / weight: C₁₉H₂₂ClN₇O₃ · 431.88 g/mol (avg)
Code names: PF-06459988

Resolves to

Compound

UNII5IE92SK9EBCAS1428774-45-1ChEMBLCHEMBL3786098

Structure

InChIKeyODMXWZROLKITMS-RISCZKNCSA-NSMILESCO[C@H]1CN(C[C@@H]1COC1=C2C(Cl)=CNC2=NC(NC2=CN(C)N=C2)=N1)C(=O)C=C

Targets

P00533EGFR

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with PF-06459988, and which of those have an active Phase 3 trial?

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