Epidermal growth factor receptor

BE0000767ProteinHumansEGFR

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:12297050, PubMed:12620237, PubMed:12873986, PubMed:15374980, PubMed:15590694, PubMed:17115032, PubMed:19560417, PubMed:21258366, PubMed:27153536, PubMed:2790960, PubMed:35538033, PubMed:9488479). It is acted on by 114 drugs in DrugBank.

Gene name
EGFR
UniProtKB entry
P00533Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,210 residues · 134,276 Da
Also known as
2.7.10.1 · ERBB · ERBB1 · HER1 · Proto-oncogene c-ErbB-1

Resolves to

Protein
UniProtP00533UniProt nameEGFR_HUMAN
Gene
HGNCHGNC:3236NCBI Gene1956GenBank757924GeneCardsEGFR
Pharmacology
IUPHAR/GtoPdb1797KEGGhsa:1956
Structure
PDB1IVOPDB1M14PDB1M17
Drugs

What you can answer from here — as of September 07, 2019

114DrugsApproved to experimental, with action, bond type and pharmacological action
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665Clinical trialsTrials of drugs acting on it, by phase and status
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56GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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470+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Epidermal growth factor receptor, how selective are they, and which programs against it are still in active trials?

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