RO-5045337

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DB14793InvestigationalSmall molecule

RO-5045337 is under investigation in clinical trial NCT01164033 (A Study of RO5045337 in Patients With Solid Tumors).

Mechanism: Pharmacologically active on E3 ubiquitin-protein ligase Mdm2
Curator reviewed
Formula / weight: C₃₈H₄₈Cl₂N₄O₄S · 727.783 g/mol (avg)
Code names: RO-5045337

Resolves to

Compound

UNIIQ8MI0X869MCAS939981-39-2ChEMBLCHEMBL2386346

Structure

InChIKeyQBGKPEROWUKSBK-QPPIDDCLSA-NSMILESCCOC1=C(C=CC(=C1)C(C)(C)C)C1=N[C@@](C)(C2=CC=C(Cl)C=C2)[C@](C)(N1C(=O)N1CCN(CCCS(C)(=O)=O)CC1)C1=CC=C(Cl)C=C1

Targets

Q00987MDM2

What you can answer from here — as of July 07, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with RO-5045337, and which of those have an active Phase 3 trial?

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