E3 ubiquitin-protein ligase Mdm2

BE0001003ProteinHumansMDM2

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526, PubMed:21317885). It is acted on by 15 drugs in DrugBank.

Gene name
MDM2
UniProtKB entry
Q00987Swiss-Prot
Cellular location
Nucleus, nucleoplasm
Residues / weight
491 residues · 55,232 Da
Also known as
2.3.2.27 · Double minute 2 protein · Hdm2 · Oncoprotein Mdm2 · p53-binding protein Mdm2

Resolves to

Protein
UniProtQ00987UniProt nameMDM2_HUMAN
Gene
HGNCHGNC:6973NCBI Gene4193GenBank338309GeneCardsMDM2
Pharmacology
IUPHAR/GtoPdb3136KEGGhsa:4193
Structure
PDB1RV1PDB1T4EPDB1T4F
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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12Clinical trialsTrials of drugs acting on it, by phase and status
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28GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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97+ReferencesStructured and connected to the statements they support
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Which approved drugs act on E3 ubiquitin-protein ligase Mdm2, how selective are they, and which programs against it are still in active trials?

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