AZD-8848

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
AZD-8848
DrugBank Accession Number
DB14868
Background

AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 569.707
Monoisotopic: 569.332567513
Chemical Formula
C29H43N7O5
Synonyms
Not Available
External IDs
  • AZD8848

Pharmacology

Indication

Not Available

Reduce drug development failure rates
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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
322ZMR6920
CAS number
866269-28-5
InChI Key
FEFIBEHSXLKJGI-UHFFFAOYSA-N
InChI
InChI=1S/C29H43N7O5/c1-3-4-16-41-28-32-26(30)25-27(33-28)36(29(38)31-25)13-7-12-35(11-6-10-34-14-17-40-18-15-34)21-23-9-5-8-22(19-23)20-24(37)39-2/h5,8-9,19H,3-4,6-7,10-18,20-21H2,1-2H3,(H,31,38)(H2,30,32,33)
IUPAC Name
methyl 2-[3-({[3-(6-amino-2-butoxy-8-oxo-8,9-dihydro-7H-purin-9-yl)propyl][3-(morpholin-4-yl)propyl]amino}methyl)phenyl]acetate
SMILES
CCCCOC1=NC2=C(NC(=O)N2CCCN(CCCN2CCOCC2)CC2=CC=CC(CC(=O)OC)=C2)C(N)=N1

References

General References
Not Available
ChemSpider
9766990

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentAllergic Rhinitis (AR)1
2CompletedTreatmentAsthma, Allergic1
1CompletedBasic ScienceHealthy Volunteers (HV)2
1CompletedBasic ScienceHealthy Volunteers (HV) / Safety / Tolerability1
1CompletedTreatmentAllergic Rhinitis (AR)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0763 mg/mLALOGPS
logP2.95ALOGPS
logP2.92Chemaxon
logS-3.9ALOGPS
pKa (Strongest Acidic)12.34Chemaxon
pKa (Strongest Basic)8.53Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count9Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area135.38 Å2Chemaxon
Rotatable Bond Count17Chemaxon
Refractivity160.92 m3·mol-1Chemaxon
Polarizability62.83 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-00dr-0010090000-8be57347fe08bb9e95ca
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-0010590000-8b3c475019c3d0a5fd53
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0gw0-0010490000-0d7a04e58dbfb6517f5e
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-014i-2000940000-859de90885d21b1d4dee
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-00di-0100960000-b0a52c72335855fb600e
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-06sl-0100950000-063051797154d39d7897
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at May 20, 2019 14:31 / Updated at June 12, 2020 16:53