AZD-8848
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- AZD-8848
- DrugBank Accession Number
- DB14868
- Background
AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 569.707
Monoisotopic: 569.332567513 - Chemical Formula
- C29H43N7O5
- Synonyms
- Not Available
- External IDs
- AZD8848
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 322ZMR6920
- CAS number
- 866269-28-5
- InChI Key
- FEFIBEHSXLKJGI-UHFFFAOYSA-N
- InChI
- InChI=1S/C29H43N7O5/c1-3-4-16-41-28-32-26(30)25-27(33-28)36(29(38)31-25)13-7-12-35(11-6-10-34-14-17-40-18-15-34)21-23-9-5-8-22(19-23)20-24(37)39-2/h5,8-9,19H,3-4,6-7,10-18,20-21H2,1-2H3,(H,31,38)(H2,30,32,33)
- IUPAC Name
- methyl 2-[3-({[3-(6-amino-2-butoxy-8-oxo-8,9-dihydro-7H-purin-9-yl)propyl][3-(morpholin-4-yl)propyl]amino}methyl)phenyl]acetate
- SMILES
- CCCCOC1=NC2=C(NC(=O)N2CCCN(CCCN2CCOCC2)CC2=CC=CC(CC(=O)OC)=C2)C(N)=N1
References
- General References
- Not Available
- External Links
- ChemSpider
- 9766990
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Allergic Rhinitis (AR) 1 2 Completed Treatment Asthma, Allergic 1 1 Completed Basic Science Healthy Volunteers (HV) 2 1 Completed Basic Science Healthy Volunteers (HV) / Safety / Tolerability 1 1 Completed Treatment Allergic Rhinitis (AR) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0763 mg/mL ALOGPS logP 2.95 ALOGPS logP 2.92 Chemaxon logS -3.9 ALOGPS pKa (Strongest Acidic) 12.34 Chemaxon pKa (Strongest Basic) 8.53 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 9 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 135.38 Å2 Chemaxon Rotatable Bond Count 17 Chemaxon Refractivity 160.92 m3·mol-1 Chemaxon Polarizability 62.83 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at May 20, 2019 14:31 / Updated at June 12, 2020 16:53