Seltorexant

DB14961InvestigationalSmall molecule

Seltorexant is under investigation in clinical trial NCT03494907 (A Study to Evaluate the Effects of Single-dose Seltorexant on Electrocardiogram Intervals in Healthy Adult Participants).

Mechanism: Pharmacologically active on Orexin receptor type 2
Curator reviewed
Formula / weight: C₂₁H₂₂FN₇O · 407.453 g/mol (avg)
Also known as: JNJ-42847922

Resolves to

Compound

UNIIAIS8N3O50BCAS1452539-75-1ChEMBLCHEMBL3586436

Structure

InChIKeySQOCEMCKYDVLMM-IYBDPMFKSA-NSMILESCC1=CC(C)=NC(=N1)N1C[C@@H]2CN(C[C@@H]2C1)C(=O)C1=C(F)C=CC=C1N1N=CC=N1

Targets

O43614HCRTR2

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

17Clinical trialsPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Seltorexant, and which of those have an active Phase 3 trial?

Answer this in Biopharma OS Sign in to your account

Create a free account or log in to explore the full data card.

Create Account