Orexin receptor type 2

BE0005865ProteinHumansHCRTR2

G protein-coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin (PubMed:26950369, PubMed:33547286, PubMed:35614071, PubMed:9491897). It is acted on by 12 drugs in DrugBank.

Gene name
HCRTR2
UniProtKB entry
O43614Swiss-Prot
Cellular location
Cell membrane
Residues / weight
444 residues · 50,694 Da
Also known as
Hypocretin receptor type 2 · ORXR2 · Ox-2-R · Ox2-R · Ox2R

Resolves to

Protein
UniProtO43614UniProt nameOX2R_HUMAN
Gene
HGNCHGNC:4849NCBI Gene3062GeneCardsHCRTR2
Pharmacology
IUPHAR/GtoPdb322KEGGhsa:3062
Structure
PDB4S0VPDB5WQCPDB5WS3
Drugs

What you can answer from here — as of September 03, 2024

12DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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40+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Orexin receptor type 2, how selective are they, and which programs against it are still in active trials?

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