Orexin receptor type 2

Details

Name

Orexin receptor type 2

Kind

protein

Synonyms

• Hypocretin receptor type 2
• Ox-2-R
• Ox2-R
• Ox2R

Gene Name

HCRTR2

UniProtKB Entry

O43614Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0013976|Orexin receptor type 2
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

Number of residues

444

Molecular Weight

50693.965

Theoretical pI

Not Available

GO Classification

Processes

chemical synaptic transmission / locomotion / phospholipase C-activating G protein-coupled receptor signaling pathway / regulation of circadian sleep/wake cycle, wakefulness / regulation of cytosolic calcium ion concentration

Components

synapse

General Function

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:26950369, PubMed:9491897). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:26950369, PubMed:9491897)

Specific Function

neuropeptide receptor activity

Pfam Domain Function

• 7tm_1 (PF00001)
• Orexin_rec2 (PF03827)

Signal Regions

Not Available

Transmembrane Regions

55-75 89-110 128-150 171-191 223-243 305-326 343-366

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0013977|Orexin receptor type 2 (HCRTR2)
ATGTCCGGCACCAAATTGGAGGACTCCCCCCCTTGTCGCAACTGGTCATCTGCTTCGGAG
CTGAATGAAACTCAAGAGCCCTTTTTAAACCCCACCGACTATGACGACGAGGAATTCCTG
CGGTACCTGTGGAGGGAATACCTGCACCCGAAAGAATATGAGTGGGTCCTGATCGCCGGG
TACATCATCGTGTTCGTCGTGGCTCTCATTGGGAACGTCCTGGTTTGTGTGGCAGTGTGG
AAGAACCACCACATGAGGACGGTAACCAACTACTTCATAGTCAATCTTTCTCTGGCTGAT
GTGCTCGTGACCATCACCTGCCTTCCAGCCACACTGGTCGTGGATATCACTGAGACCTGG
TTTTTTGGACAGTCCCTTTGCAAAGTGATTCCTTATCTACAGACCGTGTCGGTGTCTGTG
TCTGTCCTCACACTGAGCTGTATCGCCTTGGATCGGTGGTATGCAATCTGTCACCCTTTG
ATGTTTAAGAGCACAGCAAAGCGGGCCCGTAACAGCATTGTCATCATCTGGATTGTCTCC
TGCATTATAATGATTCCTCAGGCCATCGTCATGGAGTGCAGCACCGTGTTCCCAGGCTTA
GCCAATAAAACCACCCTCTTTACGGTGTGTGATGAGCGCTGGGGTGGTGAAATTTATCCC
AAGATGTACCACATCTGTTTCTTTCTGGTGACATACATGGCACCACTGTGTCTCATGGTG
TTGGCTTATCTGCAAATATTTCGCAAACTCTGGTGTCGACAGATCCCTGGAACATCATCT
GTAGTTCAGAGAAAATGGAAGCCCCTGCAGCCTGTTTCACAGCCTCGAGGGCCAGGACAG
CCAACGAAGTCCCGGATGAGCGCTGTGGCGGCTGAAATAAAGCAGATCCGAGCCAGAAGG
AAAACAGCCCGGATGTTGATGATTGTGCTTTTGGTATTTGCAATTTGCTATCTACCAATT
AGCATCCTCAATGTGCTAAAGAGAGTATTTGGGATGTTTGCCCATACTGAAGACAGAGAG
ACTGTGTATGCCTGGTTTACCTTTTCACACTGGCTTGTATATGCCAATAGTGCTGCGAAT
CCAATTATTTATAATTTTCTCAGTGGAAAATTTCGAGAGGAATTTAAAGCTGCGTTTTCT
TGCTGTTGCCTTGGAGTTCACCATCGCCAGGAGGATCGGCTCACCAGGGGACGAACTAGC
ACAGAGAGCCGGAAGTCCTTGACCACTCAAATCAGCAACTTTGATAACATATCAAAACTT
TCTGAGCAAGTTGTGCTCACTAGCATAAGCACACTCCCAGCAGCCAATGGAGCAGGACCA
CTTCAAAACTGGTAG

Chromosome Location

6

Locus

6p12.1

External Identifiers

Resource	Link
UniProtKB ID	O43614
UniProtKB Entry Name	OX2R_HUMAN
GeneCard ID	HCRTR2
HGNC ID	HGNC:4849
PDB ID(s)	4S0V, 5WQC, 5WS3, 6TPG, 6TPJ, 6TPN, 7L1U, 7L1V, 7SQO, 7SR8, 7XRR
KEGG ID	hsa:3062
IUPHAR/Guide To Pharmacology ID	322
NCBI Gene ID	3062

General References

1. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M: Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. [Article]
2. Olafsdottir BR, Rye DB, Scammell TE, Matheson JK, Stefansson K, Gulcher JR: Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. Neurology. 2001 Nov 27;57(10):1896-9. [Article]
3. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [Article]
4. Hungs M, Mignot E: Hypocretin/orexin, sleep and narcolepsy. Bioessays. 2001 May;23(5):397-408. [Article]
5. Willie JT, Chemelli RM, Sinton CM, Yanagisawa M: To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci. 2001;24:429-58. [Article]

Associated Data

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Suvorexant	approved, investigational	yes	target	antagonist	Details
Lemborexant	approved, investigational	yes	target	antagonist	Details
Daridorexant	approved	yes	target	antagonist	Details