This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Venglustat
DrugBank Accession Number
DB14966
Background

Venglustat is under investigation in clinical trial NCT01674036 (Safety, Tolerability and Pharmacokinetics of Genz-682452 in Healthy Men).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 389.49
Monoisotopic: 389.157326362
Chemical Formula
C20H24FN3O2S
Synonyms
  • GENZ-682452
  • Venglustat

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
BLP1XA3FZA
CAS number
1401090-53-6
InChI Key
YFHRCLAKZBDRHN-MRXNPFEDSA-N
InChI
InChI=1S/C20H24FN3O2S/c1-20(2,17-12-27-18(22-17)14-3-5-15(21)6-4-14)23-19(25)26-16-11-24-9-7-13(16)8-10-24/h3-6,12-13,16H,7-11H2,1-2H3,(H,23,25)/t16-/m1/s1
IUPAC Name
(3S)-1-azabicyclo[2.2.2]octan-3-yl N-{2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate
SMILES
CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)C1=CSC(=N1)C1=CC=C(F)C=C1

References

General References
Not Available
ChemSpider
34989426
ZINC
ZINC000202143443

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Active Not RecruitingTreatmentTay-Sachs Disease Sandhoff Disease1
3RecruitingTreatmentFabry's Disease2
3RecruitingTreatmentGaucher Disease, Type III1
3TerminatedTreatmentCongenital cystic kidney disease1
2Active Not RecruitingTreatmentGaucher Disease, Type 1 / Gaucher Disease, Type 31
2TerminatedTreatmentParkinson's Disease (PD)1
2, 3TerminatedTreatmentAutosomal Dominant Polycystic Kidney Disease (ADPKD)1
1CompletedBasic ScienceHealthy Subjects (HS)1
1CompletedScreeningDisorders of Sphingolipid Metabolism (Healthy Volunteers)1
1CompletedTreatmentAutosomal Dominant Polycystic Kidney Disease (ADPKD) / Healthy Subjects (HS)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00581 mg/mLALOGPS
logP3.77ALOGPS
logP3.82ChemAxon
logS-4.8ALOGPS
pKa (Strongest Acidic)13.38ChemAxon
pKa (Strongest Basic)9.01ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area54.46 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity112.78 m3·mol-1ChemAxon
Polarizability41.14 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at May 20, 2019 14:38 / Updated at February 21, 2021 18:55