This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Venglustat
- DrugBank Accession Number
- DB14966
- Background
Venglustat is under investigation in clinical trial NCT01674036 (Safety, Tolerability and Pharmacokinetics of Genz-682452 in Healthy Men).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Venglustat (DB14966)
- Weight
- Average: 389.49
Monoisotopic: 389.157326362 - Chemical Formula
- C20H24FN3O2S
- Synonyms
- GENZ-682452
- Venglustat
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- BLP1XA3FZA
- CAS number
- 1401090-53-6
- InChI Key
- YFHRCLAKZBDRHN-MRXNPFEDSA-N
- InChI
- InChI=1S/C20H24FN3O2S/c1-20(2,17-12-27-18(22-17)14-3-5-15(21)6-4-14)23-19(25)26-16-11-24-9-7-13(16)8-10-24/h3-6,12-13,16H,7-11H2,1-2H3,(H,23,25)/t16-/m1/s1
- IUPAC Name
- (3S)-1-azabicyclo[2.2.2]octan-3-yl N-{2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate
- SMILES
- CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)C1=CSC(=N1)C1=CC=C(F)C=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 34989426
- ZINC
- ZINC000202143443
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Active Not Recruiting Treatment Tay-Sachs Disease Sandhoff Disease 1 3 Recruiting Treatment Fabry's Disease 2 3 Recruiting Treatment Gaucher Disease, Type III 1 3 Terminated Treatment Congenital cystic kidney disease 1 2 Active Not Recruiting Treatment Gaucher Disease, Type 1 / Gaucher Disease, Type 3 1 2 Terminated Treatment Parkinson's Disease (PD) 1 2, 3 Terminated Treatment Autosomal Dominant Polycystic Kidney Disease （ADPKD) 1 1 Completed Basic Science Healthy Subjects (HS) 1 1 Completed Screening Disorders of Sphingolipid Metabolism (Healthy Volunteers) 1 1 Completed Treatment Autosomal Dominant Polycystic Kidney Disease （ADPKD) / Healthy Subjects (HS) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00581 mg/mL ALOGPS logP 3.77 ALOGPS logP 3.82 ChemAxon logS -4.8 ALOGPS pKa (Strongest Acidic) 13.38 ChemAxon pKa (Strongest Basic) 9.01 ChemAxon Physiological Charge 1 ChemAxon Hydrogen Acceptor Count 3 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 54.46 Å2 ChemAxon Rotatable Bond Count 5 ChemAxon Refractivity 112.78 m3·mol-1 ChemAxon Polarizability 41.14 Å3 ChemAxon Number of Rings 4 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at May 20, 2019 14:38 / Updated at February 21, 2021 18:55