Venglustat

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Venglustat
Accession Number
DB14966
Description

Venglustat is under investigation in clinical trial NCT01674036 (Safety, Tolerability and Pharmacokinetics of Genz-682452 in Healthy Men).

Type
Small Molecule
Groups
Investigational
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Structure
Thumb
Weight
Average: 389.49
Monoisotopic: 389.157326362
Chemical Formula
C20H24FN3O2S
Synonyms
  • GENZ-682452

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
BLP1XA3FZA
CAS number
1401090-53-6
InChI Key
YFHRCLAKZBDRHN-MRXNPFEDSA-N
InChI
InChI=1S/C20H24FN3O2S/c1-20(2,17-12-27-18(22-17)14-3-5-15(21)6-4-14)23-19(25)26-16-11-24-9-7-13(16)8-10-24/h3-6,12-13,16H,7-11H2,1-2H3,(H,23,25)/t16-/m1/s1
IUPAC Name
(3S)-1-azabicyclo[2.2.2]octan-3-yl N-{2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate
SMILES
CC(C)(NC(=O)O[[email protected]@H]1CN2CCC1CC2)C1=CSC(=N1)C1=CC=C(F)C=C1

References

General References
Not Available
ChemSpider
34989426
ZINC
ZINC000202143443

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3RecruitingTreatmentTay-Sachs Disease Sandhoff Disease1
2, 3RecruitingTreatmentAutosomal Dominant Polycystic Kidney Disease (ADPKD)1
2, 3RecruitingTreatmentGaucher Disease Type 1-Gaucher Disease Type 31
1CompletedBasic ScienceHealthy Volunteers1
1CompletedTreatmentAutosomal Dominant Polycystic Kidney Disease (ADPKD) / Healthy Volunteers1
1CompletedTreatmentHealthy Volunteers1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00581 mg/mLALOGPS
logP3.77ALOGPS
logP3.82ChemAxon
logS-4.8ALOGPS
pKa (Strongest Acidic)13.38ChemAxon
pKa (Strongest Basic)9.01ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area54.46 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity112.78 m3·mol-1ChemAxon
Polarizability41.14 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on May 20, 2019 08:38 / Updated on June 12, 2020 10:53

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