Ceramide glucosyltransferase

BE0000477ProteinHumansUGCG

Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi (PubMed:1532799, PubMed:8643456). It is acted on by 7 drugs in DrugBank.

Gene name
UGCG
UniProtKB entry
Q16739Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
394 residues · 44,853 Da
Also known as
2.4.1.80 · GCS · GLCT-1 · Glucosylceramide synthase · Glycosylceramide synthase

Resolves to

Protein
UniProtQ16739UniProt nameCEGT_HUMAN
Gene
HGNCHGNC:12524NCBI Gene7357GenBank1325917GeneCardsUGCG
Pharmacology
IUPHAR/GtoPdb2528KEGGhsa:7357
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ceramide glucosyltransferase, how selective are they, and which programs against it are still in active trials?

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