GLPG-0259

DB15190InvestigationalSmall molecule

GLPG-0259 is under investigation in clinical trial NCT01024517 (GLPG0259 Solid Formulation Bioavailability and Food Effect).

Mechanism: Pharmacologically active on MAP kinase-activated protein kinase 5
Curator reviewed
Formula / weight: C₂₄H₂₆N₈O₂ · 458.526 g/mol (avg)
Code names: GLPG0259

Resolves to

Compound

Structure

InChIKeyYBFGSJUVEOYPIS-OALUTQOASA-NSMILESCC(C)N1C[C@@H]2C[C@H]1CN2C1=CC=C(NC2=NC=C(N3N=CN=C23)C2=COC(=C2)C(N)=O)C=C1

Targets

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with GLPG-0259, and which of those have an active Phase 3 trial?

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