MAP kinase-activated protein kinase 5

BE0009478ProteinHumansMAPKAPK5

Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. It is acted on by 3 drugs in DrugBank.

Gene name
MAPKAPK5
UniProtKB entry
Q8IW41Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
473 residues · 54,220 Da
Also known as
2.7.11.1 · MAPK-activated protein kinase 5 · MAPKAP kinase 5 · MAPKAP-K5 · MAPKAPK-5

Resolves to

Protein
UniProtQ8IW41UniProt nameMAPK5_HUMAN
Gene
HGNCHGNC:6889NCBI Gene8550GeneCardsMAPKAPK5
Pharmacology
IUPHAR/GtoPdb2096KEGGhsa:8550
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on MAP kinase-activated protein kinase 5, how selective are they, and which programs against it are still in active trials?

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