This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Olorofim
- DrugBank Accession Number
- DB15245
- Background
Olorofim is under investigation in clinical trial NCT03340597 (Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Olorofim (DB15245)
- Weight
- Average: 498.562
Monoisotopic: 498.217952296 - Chemical Formula
- C28H27FN6O2
- Synonyms
- Olorofim
- External IDs
- F901318
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcenocoumarol The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Olorofim. Dicoumarol The therapeutic efficacy of Dicoumarol can be increased when used in combination with Olorofim. Fluindione The therapeutic efficacy of Fluindione can be increased when used in combination with Olorofim. Phenindione The therapeutic efficacy of Phenindione can be increased when used in combination with Olorofim. Phenprocoumon The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Olorofim. Warfarin The therapeutic efficacy of Warfarin can be increased when used in combination with Olorofim. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- T34SH2H9HI
- CAS number
- 1928707-56-5
- InChI Key
- SUFPWYYDCOKDLL-UHFFFAOYSA-N
- InChI
- InChI=1S/C28H27FN6O2/c1-19-16-24(20-6-4-3-5-7-20)25(33(19)2)26(36)27(37)32-22-8-10-23(11-9-22)34-12-14-35(15-13-34)28-30-17-21(29)18-31-28/h3-11,16-18H,12-15H2,1-2H3,(H,32,37)
- IUPAC Name
- 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl}-2-oxoacetamide
- SMILES
- CN1C(C)=CC(=C1C(=O)C(=O)NC1=CC=C(C=C1)N1CCN(CC1)C1=NC=C(F)C=N1)C1=CC=CC=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 58828130
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Recruiting Treatment Invasive Aspergillosis 1 2 Recruiting Treatment Invasive Fungal Infections 1 1 Completed Other Healthy Subjects (HS) 2 1 Completed Other Hepatic Impairment 1 1 Completed Other Impaired Renal Function 1 1 Completed Other Invasive Aspergillosis 1 1 Completed Other Invasive Fungal Infections 1 1 Completed Treatment Invasive Aspergillosis 7 1 Withdrawn Other Invasive Aspergillosis 1 1 Withdrawn Treatment Invasive Aspergillosis 2
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0142 mg/mL ALOGPS logP 4.17 ALOGPS logP 4.74 Chemaxon logS -4.6 ALOGPS pKa (Strongest Acidic) 12.29 Chemaxon pKa (Strongest Basic) 2.66 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 83.36 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 144.16 m3·mol-1 Chemaxon Polarizability 52.99 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at May 20, 2019 15:03 / Updated at February 21, 2021 18:55