Olorofim

DB15245InvestigationalSmall molecule

Olorofim is under investigation in clinical trial NCT03340597 (Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects).

Mechanism: Pharmacologically active on Dihydroorotate dehydrogenase (quinone), mitochondrial
Curator reviewed
Formula / weight: C₂₈H₂₇FN₆O₂ · 498.562 g/mol (avg)
Code names: F901318

Resolves to

Compound

Structure

InChIKeySUFPWYYDCOKDLL-UHFFFAOYSA-NSMILESCN1C(C)=CC(=C1C(=O)C(=O)NC1=CC=C(C=C1)N1CCN(CC1)C1=NC=C(F)C=N1)C1=CC=CC=C1

Targets

What you can answer from here — as of September 04, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

14Drug interactionsStructured to mechanism, not free text

14Clinical trialsPhase, status and sponsor resolved per trial

17+ReferencesStructured and connected to the statements they support

Which drugs share a target with Olorofim, and which of those have an active Phase 3 trial?

Create a free account or log in to explore the full data card.