Dihydroorotate dehydrogenase (quinone), mitochondrial

BE0000382ProteinHumansDHODH

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. It is acted on by 34 drugs in DrugBank.

Gene name
DHODH
UniProtKB entry
Q02127Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
395 residues · 42,867 Da
Also known as
1.3.5.2 · DHOdehase · Dihydroorotate oxidase

Resolves to

Protein
UniProtQ02127UniProt namePYRD_HUMAN
Gene
HGNCHGNC:2867NCBI Gene1723GenBank555594GeneCardsDHODH
Pharmacology
IUPHAR/GtoPdb2604KEGGhsa:1723
Structure
PDB1D3GPDB1D3HPDB2B0M
Drugs

What you can answer from here — as of September 07, 2019

34DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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104+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dihydroorotate dehydrogenase (quinone), mitochondrial, how selective are they, and which programs against it are still in active trials?

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