Petesicatib

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DB15297InvestigationalSmall molecule

Petesicatib is under investigation in clinical trial NCT02295332 (A Study of RG7625 in Healthy Volunteers).

Mechanism: Pharmacologically active on Cathepsin S
Curator reviewed
Formula / weight: C₂₅H₂₃F₆N₅O₄S · 603.54 g/mol (avg)
Code names: RG-7625 · RO-5459072

Resolves to

Compound

UNIIA26QO95U37CAS1252637-35-6ChEMBLCHEMBL4297638

Structure

InChIKeyKXAAIORSMACJSI-AEFFLSMTSA-NSMILESCN1C=C(C=N1)C1=CC(=C(C=C1)S(=O)(=O)[C@@H]1C[C@H](N(C1)C(=O)C1(CC1)C(F)(F)F)C(=O)NC1(CC1)C#N)C(F)(F)F

Targets

P25774CTSS

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Petesicatib, and which of those have an active Phase 3 trial?

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