Cathepsin S

BE0001646ProteinHumansCTSS

Thiol protease (PubMed:30612035). It is acted on by 17 drugs in DrugBank.

Gene name
CTSS
UniProtKB entry
P25774Swiss-Prot
Cellular location
Lysosome
Residues / weight
331 residues · 37,495 Da
Also known as
3.4.22.27

Resolves to

Protein
UniProtP25774UniProt nameCATS_HUMAN
Gene
HGNCHGNC:2545NCBI Gene1520GenBank248406GeneCardsCTSS
Pharmacology
IUPHAR/GtoPdb2353KEGGhsa:1520
Structure
PDB1GLOPDB1MS6PDB1NPZ
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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25GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cathepsin S, how selective are they, and which programs against it are still in active trials?

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