Atabecestat

DB15307InvestigationalSmall molecule

Atabecestat is under investigation in clinical trial NCT02211079 (A Study to Assess Effect of JNJ-54861911 on Pharmacokinetics of Cocktail Representatives for Cytochrome P450 (CYP) 3A4, CYP2B6, CYP2C9, and CYP1A2 Substrates).

Mechanism: Pharmacologically active on Beta-secretase 1
Curator reviewed
Formula / weight: C₁₈H₁₄FN₅OS · 367.4 g/mol (avg)
Also known as: JNJ-54861911

Resolves to

Compound

UNII2834W8D6GKCAS1200493-78-2ChEMBLCHEMBL3916243

Structure

InChIKeyVLLFGVHGKLDDLW-SFHVURJKSA-NSMILESC[C@]1(C=CSC(N)=N1)C1=CC(NC(=O)C2=NC=C(C=C2)C#N)=CC=C1F

Targets

P56817BACE1

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

6Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Atabecestat, and which of those have an active Phase 3 trial?

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