Beta-secretase 1

BE0000988ProteinHumansBACE1

Responsible for the proteolytic processing of the amyloid precursor protein (APP). It is acted on by 38 drugs in DrugBank.

Gene name
BACE1
UniProtKB entry
P56817Swiss-Prot
Cellular location
Cell membrane
Residues / weight
501 residues · 55,763 Da
Also known as
3.4.23.46 · Asp 2 · ASP2 · Aspartyl protease 2 · BACE

Resolves to

Protein
UniProtP56817UniProt nameBACE1_HUMAN
Gene
HGNCHGNC:933NCBI Gene23621GenBank6118539GeneCardsBACE1
Pharmacology
IUPHAR/GtoPdb2330KEGGhsa:23621
Structure
PDB1FKNPDB1M4HPDB1PY1
Drugs

What you can answer from here — as of September 07, 2019

38DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
30GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
123+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Beta-secretase 1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In