JNJ-54175446

DB15358InvestigationalSmall molecule

JNJ-54175446 is under investigation in clinical trial NCT02933762 (A Study in Healthy Participants to Evaluate the Effect of JNJ-54175446 on Amyloid Biomarkers and Cytokine Profiles in Cerebrospinal Fluid and Plasma).

Mechanism: Pharmacologically active on P2X purinoceptor 7
Curator reviewed
Formula / weight: C₁₈H₁₃ClF₄N₆O · 440.79 g/mol (avg)
Code names: JNJ-54175446

Resolves to

Compound

UNII32524GLF40CAS1627902-21-9ChEMBLCHEMBL4079239

Structure

InChIKeyCWFVVQFVGMFTBD-SECBINFHSA-NSMILESC[C@H]1N(CCC2=C1N=NN2C1=NC=C(F)C=N1)C(=O)C1=C(Cl)C(=CC=C1)C(F)(F)F

Targets

Q99572P2RX7

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

5Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with JNJ-54175446, and which of those have an active Phase 3 trial?

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