P2X purinoceptor 7

Details

Name
P2X purinoceptor 7
Kind
protein
Synonyms
  • ATP receptor
  • P2X7
  • P2Z receptor
  • Purinergic receptor
Gene Name
P2RX7
UniProtKB Entry
Q99572Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0052211|P2X purinoceptor 7
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
Number of residues
595
Molecular Weight
68584.32
Theoretical pI
Not Available
GO Classification
Functions
extracellularly ATP-gated monoatomic cation channel activity / identical protein binding
Processes
calcium-mediated signaling / cellular response to extracellular stimulus / gamma-aminobutyric acid secretion / glutamate secretion / MAPK cascade / mitochondrial depolarization / positive regulation of interleukin-1 alpha production / positive regulation of interleukin-1 beta production / positive regulation of macrophage cytokine production / positive regulation of MAPK cascade / positive regulation of monoatomic ion transmembrane transport / positive regulation of protein phosphorylation / positive regulation of protein secretion / positive regulation of T cell apoptotic process / prostaglandin secretion / protein secretion / response to xenobiotic stimulus / T cell apoptotic process / T cell mediated cytotoxicity
Components
mitochondrion
General Function
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206)
Specific Function
Atp binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
26-46 335-355
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052212|P2X purinoceptor 7 (P2RX7)
ATGCCGGCCTGCTGCAGCTGCAGTGATGTTTTCCAGTATGAGACGAACAAAGTCACTCGG
ATCCAGAGCATGAATTATGGCACCATTAAGTGGTTCTTCCACGTGATCATCTTTTCCTAC
GTTTGCTTTGCTCTGGTGAGTGACAAGCTGTACCAGCGGAAAGAGCCTGTCATCAGTTCT
GTGCACACCAAGGTGAAGGGGATAGCAGAGGTGAAAGAGGAGATCGTGGAGAATGGAGTG
AAGAAGTTGGTGCACAGTGTCTTTGACACCGCAGACTACACCTTCCCTTTGCAGGGGAAC
TCTTTCTTCGTGATGACAAACTTTCTCAAAACAGAAGGCCAAGAGCAGCGGTTGTGTCCC
GAGTATCCCACCCGCAGGACGCTCTGTTCCTCTGACCGAGGTTGTAAAAAGGGATGGATG
GACCCGCAGAGCAAAGGAATTCAGACCGGAAGGTGTGTAGTGTATGAAGGGAACCAGAAG
ACCTGTGAAGTCTCTGCCTGGTGCCCCATCGAGGCAGTGGAAGAGGCCCCCCGGCCTGCT
CTCTTGAACAGTGCCGAAAACTTCACTGTGCTCATCAAGAACAATATCGACTTCCCCGGC
CACAACTACACCACGAGAAACATCCTGCCAGGTTTAAACATCACTTGTACCTTCCACAAG
ACTCAGAATCCACAGTGTCCCATTTTCCGACTAGGAGACATCTTCCGAGAAACAGGCGAT
AATTTTTCAGATGTGGCAATTCAGGGCGGAATAATGGGCATTGAGATCTACTGGGACTGC
AACCTAGACCGTTGGTTCCATCACTGCCGTCCCAAATACAGTTTCCGTCGCCTTGACGAC
AAGACCACCAACGTGTCCTTGTACCCTGGCTACAACTTCAGATACGCCAAGTACTACAAG
GAAAACAATGTTGAGAAACGGACTCTGATAAAAGTCTTCGGGATCCGTTTTGACATCCTG
GTTTTTGGCACCGGAGGAAAATTTGACATTATCCAGCTGGTTGTGTACATCGGCTCAACC
CTCTCCTACTTCGGTCTGGCCGCTGTGTTCATCGACTTCCTCATCGACACTTACTCCAGT
AACTGCTGTCGCTCCCATATTTATCCCTGGTGCAAGTGCTGTCAGCCCTGTGTGGTCAAC
GAATACTACTACAGGAAGAAGTGCGAGTCCATTGTGGAGCCAAAGCCGACATTAAAGTAT
GTGTCCTTTGTGGATGAATCCCACATTAGGATGGTGAACCAGCAGCTACTAGGGAGAAGT
CTGCAAGATGTCAAGGGCCAAGAAGTCCCAAGACCTGCGATGGACTTCACAGATTTGTCC
AGGCTGCCCCTGGCCCTCCATGACACACCCCCGATTCCTGGACAACCAGAGGAGATACAG
CTGCTTAGAAAGGAGGCGACTCCTAGATCCAGGGATAGCCCCGTCTGGTGCCAGTGTGGA
AGCTGCCTCCCATCTCAACTCCCTGAGAGCCACAGGTGCCTGGAGGAGCTGTGCTGCCGG
AAAAAGCCGGGGGCCTGCATCACCACCTCAGAGCTGTTCAGGAAGCTGGTCCTGTCCAGA
CACGTCCTGCAGTTCCTCCTGCTCTACCAGGAGCCCTTGCTGGCGCTGGATGTGGATTCC
ACCAACAGCCGGCTGCGGCACTGTGCCTACAGGTGCTACGCCACCTGGCGCTTCGGCTCC
CAGGACATGGCTGACTTTGCCATCCTGCCCAGCTGCTGCCGCTGGAGGATCCGGAAAGAG
TTTCCGAAGAGTGAAGGGCAGTACAGTGGCTTCAAGAGTCCTTACTGA
Chromosome Location
12
Locus
12q24.31
External Identifiers
ResourceLink
UniProtKB IDQ99572
UniProtKB Entry NameP2RX7_HUMAN
GeneCard IDP2RX7
HGNC IDHGNC:8537
KEGG IDhsa:5027
IUPHAR/Guide To Pharmacology ID484
NCBI Gene ID5027
General References
  1. Rassendren F, Buell GN, Virginio C, Collo G, North RA, Surprenant A: The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. J Biol Chem. 1997 Feb 28;272(9):5482-6. doi: 10.1074/jbc.272.9.5482. [Article]
  2. Buell GN, Talabot F, Gos A, Lorenz J, Lai E, Morris MA, Antonarakis SE: Gene structure and chromosomal localization of the human P2X7 receptor. Receptors Channels. 1998;5(6):347-54. [Article]
  3. Cheewatrakoolpong B, Gilchrest H, Anthes JC, Greenfeder S: Identification and characterization of splice variants of the human P2X7 ATP channel. Biochem Biophys Res Commun. 2005 Jun 24;332(1):17-27. doi: 10.1016/j.bbrc.2005.04.087. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  7. Kim M, Jiang LH, Wilson HL, North RA, Surprenant A: Proteomic and functional evidence for a P2X7 receptor signalling complex. EMBO J. 2001 Nov 15;20(22):6347-58. doi: 10.1093/emboj/20.22.6347. [Article]
  8. Wilson HL, Wilson SA, Surprenant A, North RA: Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. J Biol Chem. 2002 Sep 13;277(37):34017-23. doi: 10.1074/jbc.M205120200. Epub 2002 Jul 9. [Article]
  9. Gonnord P, Delarasse C, Auger R, Benihoud K, Prigent M, Cuif MH, Lamaze C, Kanellopoulos JM: Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts. FASEB J. 2009 Mar;23(3):795-805. doi: 10.1096/fj.08-114637. Epub 2008 Oct 29. [Article]
  10. Lenertz LY, Wang Z, Guadarrama A, Hill LM, Gavala ML, Bertics PJ: Mutation of putative N-linked glycosylation sites on the human nucleotide receptor P2X7 reveals a key residue important for receptor function. Biochemistry. 2010 Jun 8;49(22):4611-9. doi: 10.1021/bi902083n. [Article]
  11. Gu BJ, Saunders BM, Petrou S, Wiley JS: P2X(7) is a scavenger receptor for apoptotic cells in the absence of its ligand, extracellular ATP. J Immunol. 2011 Sep 1;187(5):2365-75. doi: 10.4049/jimmunol.1101178. Epub 2011 Aug 5. [Article]
  12. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  13. Gu BJ, Zhang W, Worthington RA, Sluyter R, Dao-Ung P, Petrou S, Barden JA, Wiley JS: A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor. J Biol Chem. 2001 Apr 6;276(14):11135-42. doi: 10.1074/jbc.M010353200. Epub 2001 Jan 9. [Article]
  14. Wiley JS, Dao-Ung LP, Li C, Shemon AN, Gu BJ, Smart ML, Fuller SJ, Barden JA, Petrou S, Sluyter R: An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor. J Biol Chem. 2003 May 9;278(19):17108-13. doi: 10.1074/jbc.M212759200. Epub 2003 Feb 13. [Article]
  15. Gu BJ, Sluyter R, Skarratt KK, Shemon AN, Dao-Ung LP, Fuller SJ, Barden JA, Clarke AL, Petrou S, Wiley JS: An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor. J Biol Chem. 2004 Jul 23;279(30):31287-95. doi: 10.1074/jbc.M313902200. Epub 2004 Apr 27. [Article]
  16. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [Article]
  17. Gu BJ, Baird PN, Vessey KA, Skarratt KK, Fletcher EL, Fuller SJ, Richardson AJ, Guymer RH, Wiley JS: A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration. FASEB J. 2013 Apr;27(4):1479-87. doi: 10.1096/fj.12-215368. Epub 2013 Jan 9. [Article]
  18. Sadovnick AD, Gu BJ, Traboulsee AL, Bernales CQ, Encarnacion M, Yee IM, Criscuoli MG, Huang X, Ou A, Milligan CJ, Petrou S, Wiley JS, Vilarino-Guell C: Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis. Hum Mutat. 2017 Jun;38(6):736-744. doi: 10.1002/humu.23218. Epub 2017 Apr 13. [Article]

Associated Data

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