P2X purinoceptor 7

BE0009814ProteinHumansP2RX7

ATP-gated nonselective transmembrane cation channel that requires high millimolar concentrations of ATP for activation (PubMed:17483156, PubMed:25281740, PubMed:9038151). It is acted on by 7 drugs in DrugBank.

Gene name
P2RX7
UniProtKB entry
Q99572Swiss-Prot
Cellular location
Cell membrane
Residues / weight
595 residues · 68,584 Da
Also known as
ATP receptor · P2X7 · P2Z receptor · Purinergic receptor

Resolves to

Protein
UniProtQ99572UniProt nameP2RX7_HUMAN
Gene
HGNCHGNC:8537NCBI Gene5027GeneCardsP2RX7
Pharmacology
IUPHAR/GtoPdb484KEGGhsa:5027
Structure
PDB9E3MPDB9E3NPDB9E3O
Drugs

What you can answer from here — as of January 22, 2020

7DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
39GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
39+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on P2X purinoceptor 7, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In