Tallimustine

DB15466ExperimentalSmall molecule

Tallimustine is an alkylating agent previously investigated for it's antitumor activity but was stopped due to severe myelotoxicity. Tallimustine, a benzoyl mustard derivative of distamycin A, is an alkylating agent that binds to the minor groove of DNA.

Mechanism: Tallimustine binds to the minor groove of DNA while avoiding targets like glutathione. Currently, the mechanism of DNA minor groove binding agents is poorly understood. Though, they may act by directly inhibiting the interaction of protein and DNA.
Curator reviewed · 3 references
Primary indication: Tallimustine was being investigated for its use in treating tumors.Curator reviewed
Formula / weight: C₃₂H₃₈Cl₂N₁₀O₄ · 697.62 g/mol (avg)

Resolves to

Compound

UNII71193OXG6SCAS115308-98-0ChEMBLCHEMBL89705

Structure

InChIKeyARKYUICTMUZVEW-UHFFFAOYSA-NSMILESCN1C=C(NC(=O)C2=CC(NC(=O)C3=CC(NC(=O)C4=CC=C(C=C4)N(CCCl)CCCl)=CN3C)=CN2C)C=C1C(=O)NCCC(N)=N

Targets

P25025CXCR2

What you can answer from here — as of August 30, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

39Drug interactionsStructured to mechanism, not free text

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Tallimustine, and which of those have an active Phase 3 trial?

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