C-X-C chemokine receptor type 2

BE0010516ProteinHumansCXCR2

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). It is acted on by 14 drugs in DrugBank.

Gene name
CXCR2
UniProtKB entry
P25025Swiss-Prot
Cellular location
Cell membrane
Residues / weight
360 residues · 40,759 Da
Also known as
CDw128b · CXC-R2 · CXCR-2 · GRO/MGSA receptor · High affinity interleukin-8 receptor B

Resolves to

Protein
UniProtP25025UniProt nameCXCR2_HUMAN
Gene
HGNCHGNC:6027NCBI Gene3579GeneCardsCXCR2
Pharmacology
IUPHAR/GtoPdb69KEGGhsa:3579
Structure
PDB4Q3HPDB5TYTPDB6KVA
Drugs

What you can answer from here — as of October 31, 2023

14DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on C-X-C chemokine receptor type 2, how selective are they, and which programs against it are still in active trials?

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