C-X-C chemokine receptor type 2
Details
- Name
- C-X-C chemokine receptor type 2
- Kind
- protein
- Synonyms
- CDw128b
- CXC-R2
- CXCR-2
- GRO/MGSA receptor
- High affinity interleukin-8 receptor B
- IL-8 receptor type 2
- IL-8R B
- IL8RB
- Gene Name
- CXCR2
- UniProtKB Entry
- P25025Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0053319|C-X-C chemokine receptor type 2 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
- Number of residues
- 360
- Molecular Weight
- 40758.735
- Theoretical pI
- Not Available
- GO Classification
- Not Available
- General Function
- Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2
- Specific Function
- C-c chemokine binding
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- Not Available
- Transmembrane Regions
- 49-75 85-105 121-142 164-183 209-231 252-273 295-315
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0053320|C-X-C chemokine receptor type 2 (CXCR2) ATGGAAGATTTTAACATGGAGAGTGACAGCTTTGAAGATTTCTGGAAAGGTGAAGATCTT AGTAATTACAGTTACAGCTCTACCCTGCCCCCTTTTCTACTAGATGCCGCCCCATGTGAA CCAGAATCCCTGGAAATCAACAAGTATTTTGTGGTCATTATCTATGCCCTGGTATTCCTG CTGAGCCTGCTGGGAAACTCCCTCGTGATGCTGGTCATCTTATACAGCAGGGTCGGCCGC TCCGTCACTGATGTCTACCTGCTGAACCTAGCCTTGGCCGACCTACTCTTTGCCCTGACC TTGCCCATCTGGGCCGCCTCCAAGGTGAATGGCTGGATTTTTGGCACATTCCTGTGCAAG GTGGTCTCACTCCTGAAGGAAGTCAACTTCTATAGTGGCATCCTGCTACTGGCCTGCATC AGTGTGGACCGTTACCTGGCCATTGTCCATGCCACACGCACACTGACCCAGAAGCGCTAC TTGGTCAAATTCATATGTCTCAGCATCTGGGGTCTGTCCTTGCTCCTGGCCCTGCCTGTC TTACTTTTCCGAAGGACCGTCTACTCATCCAATGTTAGCCCAGCCTGCTATGAGGACATG GGCAACAATACAGCAAACTGGCGGATGCTGTTACGGATCCTGCCCCAGTCCTTTGGCTTC ATCGTGCCACTGCTGATCATGCTGTTCTGCTACGGATTCACCCTGCGTACGCTGTTTAAG GCCCACATGGGGCAGAAGCACCGGGCCATGCGGGTCATCTTTGCTGTCGTCCTCATCTTC CTGCTCTGCTGGCTGCCCTACAACCTGGTCCTGCTGGCAGACACCCTCATGAGGACCCAG GTGATCCAGGAGACCTGTGAGCGCCGCAATCACATCGACCGGGCTCTGGATGCCACCGAG ATTCTGGGCATCCTTCACAGCTGCCTCAACCCCCTCATCTACGCCTTCATTGGCCAGAAG TTTCGCCATGGACTCCTCAAGATTCTAGCTATACATGGCTTGATCAGCAAGGACTCCCTG CCCAAAGACAGCAGGCCTTCCTTTGTTGGCTCTTCTTCAGGGCACACTTCCACTACTCTC TAA
- Chromosome Location
- 2
- Locus
- 2q35
- External Identifiers
Resource Link UniProtKB ID P25025 UniProtKB Entry Name CXCR2_HUMAN GeneCard ID CXCR2 HGNC ID HGNC:6027 PDB ID(s) 4Q3H, 5TYT, 6KVA, 6KVF, 6LFM, 6LFO KEGG ID hsa:3579 IUPHAR/Guide To Pharmacology ID 69 NCBI Gene ID 3579 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Tallimustine experimental yes target antagonist Details Indoprofen withdrawn yes target inhibitor Details SX-682 investigational yes target inhibitor Details AZD-5069 investigational yes target inhibitor Details Elubrixin investigational yes target antagonist Details Danirixin investigational yes target modulator Details Reparixin investigational yes target modulator Details Ibuprofen approved yes target inhibitor Details Clotrimazole approved, vet_approved yes target modulator Details