Echinomycin

DB15582ExperimentalSmall molecule

Echinomycin is a cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis.

Mechanism: Pharmacologically active on Hypoxia-inducible factor 1-alpha and Hypoxia-inducible factor 1
Curator reviewed
Formula / weight: C₅₁H₆₄N₁₂O₁₂S₂ · 1101.27 g/mol (avg)
Also known as: Quinomycin A
Code names: S-426-S (Lepetit) · SK 302B

Resolves to

Compound

UNIITG824J6RQTCAS512-64-1

Structure

InChIKeyAUJXLBOHYWTPFV-VITLIGDRSA-NSMILES

CSC1SC[C@@H]2N(C)C(=O)[C@H](C)NC(=O)[C@@H](COC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1N(C)C(=O)[C@H](C)NC(=O)[C@@H](COC(=O)[C@H](C(C)C)N(C)C2=O)NC(=O)C1=NC2=C(C=CC=C2)N=C1)NC(=O)C1=NC2=C(C=CC=C2)N=C1

Targets

Q16665HIF1A

What you can answer from here — as of July 08, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Echinomycin, and which of those have an active Phase 3 trial?

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