NAV

COVID-19 convalescent plasma

Identification

Generic Name
COVID-19 convalescent plasma
DrugBank Accession Number
DB15692
Background

COVID-19 convalescent plasma is plasma collected from patients who have acquired and subsequently recovered from COVID-19 and which contains antibodies against the causative agent SARS-CoV-2.2 This investigational COVID-19 treatment is currently available through three main pathways: use in registered clinical trials, use through the expanded access COVID-19 protocol (21 CFR 312.305), and use for single patients through an emergency IND (eIND; 21 CFR 312.310).2

Although there are no formal clinical trial results for the safety or efficacy of COVID-19 convalescent plasma, early results from 5000 patients under the FDA expanded access program suggest that convalescent plasma transfusion in COVID-19 patients is safe.1

Type
Biotech
Groups
Investigational
Synonyms
  • Convalescent plasma (COVID-19)

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
YM6LN8TU2V
CAS number
Not Available

References

General References
  1. Joyner MJ, Wright RS, Fairweather D, Senefeld JW, Bruno KA, Klassen SA, Carter RE, Klompas AM, Wiggins CC, Shepherd JR, Rea RF, Whelan ER, Clayburn AJ, Spiegel MR, Johnson PW, Lesser ER, Baker SE, Larson KF, Ripoll JG, Andersen KJ, Hodge DO, Kunze KL, Buras MR, Vogt MN, Herasevich V, Dennis JJ, Regimbal RJ, Bauer PR, Blair JE, van Buskirk CM, Winters JL, Stubbs JR, Paneth NS, Verdun NC, Marks P, Casadevall A: Early safety indicators of COVID-19 convalescent plasma in 5,000 patients. J Clin Invest. 2020 Jun 11. pii: 140200. doi: 10.1172/JCI140200. [Article]
  2. FDA recommendations for investigational COVID-19 convalescent plasma [Link]
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentCoronavirus Disease 2019 (COVID‑19)2
3CompletedTreatmentCoronavirus Disease 2019 (COVID‑19) / COVID1
3CompletedTreatmentCoronavirus Disease 2019 (COVID‑19) / COVID-19 Pneumonia1
3RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19) / Infections, Coronavirus / Virus Diseases / Virus Infection, RNA1
3RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19) / Severe Acute Respiratory Syndrome Coronavirus 21
3TerminatedTreatmentCoronavirus Disease 2019 (COVID‑19)2
3TerminatedTreatmentCoronavirus Disease 2019 (COVID‑19) / COVID / Infections, Coronavirus / Viral Pneumonia1
3TerminatedTreatmentCoronavirus Disease 2019 (COVID‑19) / COVID / Infectious Diseases1
2Active Not RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19)1
2Active Not RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19) / Infections, Coronavirus / Mechanical Ventilation Complication / Respiratory Failure / Severe Acute Respiratory Syndrome (SARS)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Liquid
Experimental Properties
Not Available

Drug created at June 16, 2020 20:31 / Updated at June 17, 2020 22:27