Spike glycoprotein

BE0010022ProteinSARS-CoV-2S

Spike protein S1 Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. It is acted on by 50 drugs in DrugBank.

Gene name
S
UniProtKB entry
P0DTC2Swiss-Prot
Cellular location
Virion membrane
Residues / weight
1,273 residues · 141,177 Da
Also known as
E2 · Peplomer protein · S glycoprotein

Resolves to

Protein
UniProtP0DTC2UniProt nameSPIKE_SARS2
Gene
NCBI Gene43740568
Structure
PDB6LVNPDB6LXTPDB6LZG
Drugs

What you can answer from here — as of October 07, 2020

50DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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114+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Spike glycoprotein, how selective are they, and which programs against it are still in active trials?

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