Retifanlimab

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Retifanlimab
DrugBank Accession Number
DB15766
Background

Not Available

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • Retifanlimab
External IDs
  • AEX-1188
  • AEX1188
  • INCMGA-00012
  • INCMGA00012
  • MGA-012
  • MGA012
  • WHO 11095

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UProgrammed cell death protein 1
inhibitor
antibody
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
2Y3T5IF01Z
CAS number
2079108-44-2

References

General References
Not Available
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3RecruitingTreatmentMetastatic Non-squamous Non Small Cell Lung Cancer / Metastatic Squamous Non-small Cell Lung Cancer1
3RecruitingTreatmentSquamous Cell Carcinoma of the Anal Canal1
3WithdrawnTreatmentNon-Small Cell Lung Carcinoma (NSCLC)1
2Active Not RecruitingTreatmentLocally Advanced Renal Cell Carcinoma / Locally Advanced Urothelial Cancer / Metastatic Clear Cell Renal Cell Carcinoma / Metastatic Melanoma / Metastatic Non-Small Cell Lung Cancer / Metastatic Urothelial Cancer / Unresectable Melanoma1
2Active Not RecruitingTreatmentSquamous Cell Carcinoma of Anal Canal1
2Not Yet RecruitingTreatmentAdvanced Malignancies1
2Not Yet RecruitingTreatmentAdvanced Neuroendocrine Neoplasm / Carcinoid Syndrome1
2Not Yet RecruitingTreatmentEsophageal Cancers1
2Not Yet RecruitingTreatmentTransitional Cell, Carcinoma1
2RecruitingTreatmentAnatomic Stage IV Breast Cancer AJCC v8 / Locally Advanced Breast Carcinoma / Metastatic Triple-Negative Breast Carcinoma / Prognostic Stage IV Breast Cancer AJCC v8 / Triple Negative Breast Cancer (TNBC)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Targets

Drugtargets
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
Antibody
General Function
Signal transducer activity
Specific Function
Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. ...
Gene Name
PDCD1
Uniprot ID
Q15116
Uniprot Name
Programmed cell death protein 1
Molecular Weight
31646.635 Da

Drug created on August 20, 2020 19:21 / Updated on February 21, 2021 18:55