Programmed cell death protein 1

BE0003436ProteinHumansPDCD1

Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005, PubMed:31754127, PubMed:32184441, PubMed:37208329). It is acted on by 50 drugs in DrugBank.

Gene name
PDCD1
UniProtKB entry
Q15116Swiss-Prot
Cellular location
Cell membrane
Residues / weight
288 residues · 31,647 Da
Also known as
hPD-1 · PD1 · Protein PD-1

Resolves to

Protein
UniProtQ15116UniProt namePDCD1_HUMAN
Gene
HGNCHGNC:8760NCBI Gene5133GeneCardsPDCD1
Pharmacology
IUPHAR/GtoPdb2760KEGGhsa:5133
Structure
PDB2M2DPDB3RRQPDB4ZQK
Drugs

What you can answer from here — as of September 07, 2019

50DrugsApproved to experimental, with action, bond type and pharmacological action
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647Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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137+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Programmed cell death protein 1, how selective are they, and which programs against it are still in active trials?

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