Carmoterol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Carmoterol is a long acting beta-2 agonist indicated in the treatment of COPD, asthma, and chronic bronchitis.

Generic Name
Carmoterol
DrugBank Accession Number
DB15784
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 368.433
Monoisotopic: 368.173607261
Chemical Formula
C21H24N2O4
Synonyms
  • Carmoterol
  • Quinoterol
External IDs
  • CHF 4226
  • CHF-4226
  • TA-2005

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
LUXNID 2/200 MCG INHALASYON IÇIN TOZ IÇEREN BLISTER,60 DOZCarmoterol (2 mcg) + Ciclesonide (200 mcg)PowderRespiratory (inhalation)NEUTEC İNHALER İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
LUXNID 2/200 MCG INHALASYON IÇIN TOZ IÇEREN KAPSÜL,120 KAPSÜLCarmoterol (2 mcg) + Ciclesonide (200 mcg)PowderRespiratory (inhalation)NEUTEC İNHALER İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
LUXNID 2/200 MCG INHALASYON IÇIN TOZ IÇIEREN KAPSÜL,60 KAPSÜLCarmoterol (2 mcg) + Ciclesonide (200 mcg)PowderRespiratory (inhalation)NEUTEC İNHALER İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
LUXNID 2/400 MCG INHALASYON IÇIN TOZ IÇEREN BLISTER ,60 DOZCarmoterol (2 mcg) + Ciclesonide (400 mcg)PowderRespiratory (inhalation)NEUTEC İNHALER İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
LUXNID 2/400 MCG INHALASYON IÇIN TOZ IÇEREN KAPSÜL,120 KAPSÜLCarmoterol (2 mcg) + Ciclesonide (400 mcg)PowderRespiratory (inhalation)NEUTEC İNHALER İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
LUXNID 2/400 MCG INHALASYON IÇIN TOZ IÇEREN KAPSÜL,60 KAPSÜLCarmoterol (2 mcg) + Ciclesonide (400 mcg)PowderRespiratory (inhalation)NEUTEC İNHALER İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
MATEC 2/200 MCG INHALASYON IÇIN TOZ IÇEREN BLISTER , 60 DOZCarmoterol (2 mcg) + Mometasone furoate (200 mcg)PowderRespiratory (inhalation)NEUTEC İNHALER İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
MATEC 2/200 MCG INHALASYON TOZ IÇEREN KAPSÜL , 120 KAPSÜLCarmoterol (2 mcg) + Mometasone furoate (200 mcg)Capsule; PowderRespiratory (inhalation)NEUTEC İNHALER İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
MATEC 2/200 MCG INHALASYON TOZ IÇEREN KAPSÜL , 60 KAPSÜLCarmoterol (2 mcg) + Mometasone furoate (200 mcg)Capsule; PowderRespiratory (inhalation)NEUTEC İNHALER İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
MATEC 4/400 MCG INHALASYON IÇIN TOZ IÇEREN BLISTER , 60 DOZCarmoterol (4 mcg) + Mometasone furoate (400 mcg)PowderRespiratory (inhalation)NEUTEC İNHALER İLAÇ SAN. VE TİC. A.Ş.2020-08-14Not applicableTurkey flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
9810NUL4D1
CAS number
147568-66-9
InChI Key
IHOXNOQMRZISPV-YJYMSZOUSA-N
InChI
InChI=1S/C21H24N2O4/c1-13(11-14-3-5-15(27-2)6-4-14)22-12-19(25)16-7-9-18(24)21-17(16)8-10-20(26)23-21/h3-10,13,19,22,24-25H,11-12H2,1-2H3,(H,23,26)/t13-,19+/m1/s1
IUPAC Name
8-hydroxy-5-[(1R)-1-hydroxy-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one
SMILES
COC1=CC=C(C[C@@H](C)NC[C@H](O)C2=CC=C(O)C3=C2C=CC(=O)N3)C=C1

References

General References
  1. TITCK Product Information: Luxnid (carmoterol hydrochloride/ciclesonide) powder for inhalation [Link]
  2. TITCK Product Information: ROPITAL (carmoterol and tiotropium) powder for inhalation [Link]
ChemSpider
57545
ChEMBL
CHEMBL1094785
ZINC
ZINC000034853956
PDBe Ligand
WHJ
Wikipedia
Carmoterol
PDB Entries
2y02

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)3
1CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
PowderRespiratory (inhalation)
PowderRespiratory (inhalation)
Capsule; powderRespiratory (inhalation)
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0188 mg/mLALOGPS
logP1.95ALOGPS
logP1.49ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)8.52ChemAxon
pKa (Strongest Basic)9.76ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area90.82 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity106.72 m3·mol-1ChemAxon
Polarizability39.77 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on August 24, 2020 13:53 / Updated on May 14, 2021 01:08