Beta-2 adrenergic receptor

BE0000694ProteinHumansADRB2

G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways (PubMed:2831218, PubMed:7915137). It is acted on by 107 drugs in DrugBank.

Gene name
ADRB2
UniProtKB entry
P07550Swiss-Prot
Cellular location
Cell membrane
Residues / weight
413 residues · 46,458 Da
Also known as
ADRB2R · B2AR · Beta-2 adrenoceptor · Beta-2 adrenoreceptor

Resolves to

Protein
UniProtP07550UniProt nameADRB2_HUMAN
Gene
HGNCHGNC:286NCBI Gene154GenBank29371GeneCardsADRB2
Pharmacology
IUPHAR/GtoPdb29KEGGhsa:154
Structure
PDB1GQ4PDB2R4RPDB2R4S
Drugs

What you can answer from here — as of September 07, 2019

107DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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25GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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443+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Beta-2 adrenergic receptor, how selective are they, and which programs against it are still in active trials?

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