Sodium metabisulfite

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Sodium metabisulfite is an ingredient used in products to treat dehydration and replace electrolytes.

Generic Name
Sodium metabisulfite
DrugBank Accession Number
DB15842
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 190.09
Monoisotopic: 189.89825401
Chemical Formula
Na2O5S2
Synonyms
  • Disodium pentaoxodisulfate
  • Disodium pyrosulfite
  • Disodium pyrosulphite
  • Disulfurous acid, disodium salt
  • Sodium metabisulfite
  • Sodium metabisulphite
  • Sodium pyrosulfite
  • Sodium pyrosulphite
External IDs
  • E-223
  • INS NO.223
  • INS-223

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatDehydrationCombination Product in combination with: Sodium acetate (DB09395), Potassium chloride (DB00761), D-glucose (DB01914), Dipotassium phosphate (DB09414), Sodium chloride (DB09153)••••••••••••••••••••••••••• ••••••••
Used in combination to treatPotassium deficiencyCombination Product in combination with: Dipotassium phosphate (DB09414), Sodium chloride (DB09153), D-glucose (DB01914), Sodium acetate (DB09395), Potassium chloride (DB00761)••••••••••••••••••••••••••• ••••••••
Used in combination to treatPotassium deficiencyCombination Product in combination with: Potassium chloride (DB00761), Dipotassium phosphate (DB09414), Sodium acetate (DB09395), Sodium chloride (DB09153), D-glucose (DB01914)••••••••••••••••••••••••••• ••••••••
Used in combination to treatMild metabolic acidosisCombination Product in combination with: Potassium chloride (DB00761), Sodium chloride (DB09153), Sodium acetate (DB09395), D-glucose (DB01914), Dipotassium phosphate (DB09414)••••••••••••••••••••••••••• ••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
EUROPERSOL WITH DEXTROSE 1.5% PERITONEAL DIALYSIS SOLUTIONSodium metabisulfite (30 mg/100ml) + Calcium chloride dihydrate (25.7 mg/100ml) + D-glucose monohydrate (1.5 g/100ml) + Sodium lactate (392 mg/100ml) + Magnesium chloride hexahydrate (15.2 mg/100ml) + Sodium chloride (550 mg/100ml)SolutionIntraperitonealJOYSON PTE. LTD.1998-10-14Not applicableSingapore flag
EUROPERSOL WITH DEXTROSE 4.25% PERITONEAL DIALYSIS SOLUTIONSodium metabisulfite (30 mg/100ml) + Calcium chloride dihydrate (25.7 mg/100ml) + D-glucose monohydrate (4.25 g/100ml) + Sodium lactate (392 mg/100ml) + Magnesium chloride hexahydrate (15.2 mg/100ml) + Sodium chloride (550 mg/100ml)SolutionIntraperitonealJOYSON PTE. LTD.1998-10-14Not applicableSingapore flag
NEOFLEKS IZOPLEN-M % 5 DEKSTROZLU DENGELI ELEKTROLIT IÇEREN INFÜZYON IÇIN ÇÖZELTI 1000 ML SETLISodium metabisulfite (0.21 g/L) + D-glucose monohydrate (55 g/L) + Dipotassium phosphate (1.3 g/L) + Potassium chloride (1.5 g/L) + Sodium acetate (2.8 g/L) + Sodium chloride (0.91 g/L)SolutionIntravenousTURKTIPSAN SAĞLIK TURİZM EĞİTİM VE TİC. A.Ş.2011-06-07Not applicableTurkey flag
NEOFLEKS IZOPLEN-M % 5 DEKSTROZLU DENGELI ELEKTROLIT IÇEREN INFÜZYON IÇIN ÇÖZELTI 1000 ML SETSIZSodium metabisulfite (0.21 g/L) + D-glucose monohydrate (55 g/L) + Dipotassium phosphate (1.3 g/L) + Potassium chloride (1.5 g/L) + Sodium acetate (2.8 g/L) + Sodium chloride (0.91 g/L)SolutionIntravenousTURKTIPSAN SAĞLIK TURİZM EĞİTİM VE TİC. A.Ş.2011-06-07Not applicableTurkey flag
NEOFLEKS IZOPLEN-M % 5 DEKSTROZLU DENGELI ELEKTROLIT IÇEREN INFÜZYON IÇIN ÇÖZELTI 500 ML SETLISodium metabisulfite (0.21 g/L) + D-glucose monohydrate (55 g/L) + Dipotassium phosphate (1.3 g/L) + Potassium chloride (1.5 g/L) + Sodium acetate (2.8 g/L) + Sodium chloride (0.91 g/L)SolutionIntravenousTURKTIPSAN SAĞLIK TURİZM EĞİTİM VE TİC. A.Ş.2011-06-07Not applicableTurkey flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
4VON5FNS3C
CAS number
7681-57-4
InChI Key
HRZFUMHJMZEROT-UHFFFAOYSA-L
InChI
InChI=1S/2Na.H2O5S2/c;;1-6(2)7(3,4)5/h;;(H,1,2)(H,3,4,5)/q2*+1;/p-2
IUPAC Name
disodium sulfinatosulfonate
SMILES
[Na+].[Na+].[O-]S(=O)S([O-])(=O)=O

References

General References
  1. TITCK Product Information: NEOFLEKS IZOPLEN-M (D-glucose monohydrate, dipotassium phosphate, potassium chloride, sodium acetate, sodium chloride, sodium metabisulfite) injection [Link]
ChemSpider
571015
RxNav
36696
ChEBI
114786
ChEMBL
CHEMBL2016976
Wikipedia
Sodium_metabisulfite

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2Not Yet RecruitingTreatmentCalcinosis / Systemic Sclerosis (SSc)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionIntraperitoneal25.7 mg/100ml
SolutionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-1.6Chemaxon
pKa (Strongest Acidic)-2.7Chemaxon
Physiological Charge-2Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area97.33 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity18.73 m3·mol-1Chemaxon
Polarizability9.14 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-118.161974
predicted
DarkChem Lite v0.1.0
[M-H]-111.25476
predicted
DeepCCS 1.0 (2019)
[M+H]+113.56268
predicted
DeepCCS 1.0 (2019)
[M+Na]+120.08003
predicted
DeepCCS 1.0 (2019)

Drug created at September 16, 2020 19:12 / Updated at May 14, 2021 01:08