Tyrosinase

BE0000252ProteinHumansTYR

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. It is acted on by 40 drugs in DrugBank.

Gene name
TYR
UniProtKB entry
P14679Swiss-Prot
Cellular location
Melanosome membrane
Residues / weight
529 residues · 60,393 Da
Also known as
1.14.18.1 · LB24-AB · Monophenol monooxygenase · SK29-AB · Tumor rejection antigen AB

Resolves to

Protein
UniProtP14679UniProt nameTYRO_HUMAN
Gene
HGNCHGNC:12442NCBI Gene7299GenBank340037GeneCardsTYR
Pharmacology
IUPHAR/GtoPdb2643KEGGhsa:7299
Structure
PDB7RK7
Drugs

What you can answer from here — as of September 07, 2019

40DrugsApproved to experimental, with action, bond type and pharmacological action
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19Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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128+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosinase, how selective are they, and which programs against it are still in active trials?

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