This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Foslinanib
- DrugBank Accession Number
- DB16172
- Background
Foslinanib is under investigation in clinical trial NCT03600233 (Study of CVM-1118 for Patients With Advanced Neuroendocrine Tumors).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Foslinanib (DB16172)
- Weight
- Average: 365.253
Monoisotopic: 365.046452304 - Chemical Formula
- C16H13FNO6P
- Synonyms
- Foslinanib
- Trx-818 free acid
- External IDs
- CVM-1118
- CVM-1118 FREE ACID
- TRX 818
- TRX-818
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 2X2DNM7NGX
- CAS number
- 1256037-60-1
- InChI Key
- ZDWFMAHQGDEALT-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H13FNO6P/c1-23-14-6-5-11-15(16(14)24-25(20,21)22)13(19)8-12(18-11)9-3-2-4-10(17)7-9/h2-8H,1H3,(H,18,19)(H2,20,21,22)
- IUPAC Name
- {[2-(3-fluorophenyl)-6-methoxy-4-oxo-1,4-dihydroquinolin-5-yl]oxy}phosphonic acid
- SMILES
- COC1=C(OP(O)(O)=O)C2=C(NC(=CC2=O)C2=CC(F)=CC=C2)C=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 26374637
- ChEMBL
- CHEMBL1615993
- ZINC
- ZINC000064447756
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Recruiting Treatment Advanced Malignant Neoplasm / Hepatocellular Carcinoma 1 2 Recruiting Treatment Gastroenteropancreatic Neuroendocrine Tumors / Lung Neuroendocrine Neoplasm / Neuroendocrine Carcinomas (NEC) / Neuroendocrine Tumors / Pancreatic Neuroendocrine Tumor 1 2 Terminated Treatment Advanced Malignant Neoplasm / Hepatocellular Carcinoma 1 1 Completed Treatment Advanced Malignant Neoplasm 1 1 Completed Treatment Advanced Malignant Neoplasm / Carcinoma 2
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0231 mg/mL ALOGPS logP 2.02 ALOGPS logP 2.28 Chemaxon logS -4.2 ALOGPS pKa (Strongest Acidic) 1.59 Chemaxon pKa (Strongest Basic) 0.3 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 105.09 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 90.24 m3·mol-1 Chemaxon Polarizability 32.85 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at December 15, 2020 18:14 / Updated at February 21, 2021 18:55