This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Foslinanib
- DrugBank Accession Number
- DB16172
- Background
Foslinanib is under investigation in clinical trial NCT03600233 (Study of CVM-1118 for Patients With Advanced Neuroendocrine Tumors).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Foslinanib (DB16172)
- Weight
- Average: 365.253
Monoisotopic: 365.046452304 - Chemical Formula
- C16H13FNO6P
- Synonyms
- Foslinanib
- Trx-818 free acid
- External IDs
- CVM-1118
- CVM-1118 FREE ACID
- TRX 818
- TRX-818
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 2X2DNM7NGX
- CAS number
- 1256037-60-1
- InChI Key
- ZDWFMAHQGDEALT-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H13FNO6P/c1-23-14-6-5-11-15(16(14)24-25(20,21)22)13(19)8-12(18-11)9-3-2-4-10(17)7-9/h2-8H,1H3,(H,18,19)(H2,20,21,22)
- IUPAC Name
- {[2-(3-fluorophenyl)-6-methoxy-4-oxo-1,4-dihydroquinolin-5-yl]oxy}phosphonic acid
- SMILES
- COC1=C(OP(O)(O)=O)C2=C(NC(=CC2=O)C2=CC(F)=CC=C2)C=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 26374637
- ChEMBL
- CHEMBL1615993
- ZINC
- ZINC000064447756
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Active Not Recruiting Treatment Cancer, Advanced / Hepatocellular Carcinoma 1 2 Recruiting Treatment Cancer, Advanced / Hepatocellular Carcinoma 1 2 Recruiting Treatment Gastroenteropancreatic Neuroendocrine Tumors / Lung Neuroendocrine Neoplasm / Neuroendocrine Carcinomas / Neuroendocrine Tumors / Progressive Neuroendocrine Tumors of pancreatic origin 1 1 Active Not Recruiting Treatment Cancer, Advanced 1 1 Completed Treatment Cancer, Advanced / Carcinoma 2
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0231 mg/mL ALOGPS logP 2.02 ALOGPS logP 2.28 ChemAxon logS -4.2 ALOGPS pKa (Strongest Acidic) 1.59 ChemAxon pKa (Strongest Basic) 0.3 ChemAxon Physiological Charge -2 ChemAxon Hydrogen Acceptor Count 6 ChemAxon Hydrogen Donor Count 3 ChemAxon Polar Surface Area 105.09 Å2 ChemAxon Rotatable Bond Count 4 ChemAxon Refractivity 90.24 m3·mol-1 ChemAxon Polarizability 32.85 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at December 15, 2020 18:14 / Updated at February 21, 2021 18:55