This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Foslinanib
DrugBank Accession Number
DB16172
Background

Foslinanib is under investigation in clinical trial NCT03600233 (Study of CVM-1118 for Patients With Advanced Neuroendocrine Tumors).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 365.253
Monoisotopic: 365.046452304
Chemical Formula
C16H13FNO6P
Synonyms
  • Foslinanib
  • Trx-818 free acid
External IDs
  • CVM-1118
  • CVM-1118 FREE ACID
  • TRX 818
  • TRX-818

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
2X2DNM7NGX
CAS number
1256037-60-1
InChI Key
ZDWFMAHQGDEALT-UHFFFAOYSA-N
InChI
InChI=1S/C16H13FNO6P/c1-23-14-6-5-11-15(16(14)24-25(20,21)22)13(19)8-12(18-11)9-3-2-4-10(17)7-9/h2-8H,1H3,(H,18,19)(H2,20,21,22)
IUPAC Name
{[2-(3-fluorophenyl)-6-methoxy-4-oxo-1,4-dihydroquinolin-5-yl]oxy}phosphonic acid
SMILES
COC1=C(OP(O)(O)=O)C2=C(NC(=CC2=O)C2=CC(F)=CC=C2)C=C1

References

General References
Not Available
ChemSpider
26374637
ChEMBL
CHEMBL1615993
ZINC
ZINC000064447756

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2Active Not RecruitingTreatmentCancer, Advanced / Hepatocellular Carcinoma1
2RecruitingTreatmentCancer, Advanced / Hepatocellular Carcinoma1
2RecruitingTreatmentGastroenteropancreatic Neuroendocrine Tumors / Lung Neuroendocrine Neoplasm / Neuroendocrine Carcinomas / Neuroendocrine Tumors / Progressive Neuroendocrine Tumors of pancreatic origin1
1Active Not RecruitingTreatmentCancer, Advanced1
1CompletedTreatmentCancer, Advanced / Carcinoma2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0231 mg/mLALOGPS
logP2.02ALOGPS
logP2.28ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)1.59ChemAxon
pKa (Strongest Basic)0.3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area105.09 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity90.24 m3·mol-1ChemAxon
Polarizability32.85 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at December 15, 2020 18:14 / Updated at February 21, 2021 18:55