This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- HSK-3486
- DrugBank Accession Number
- DB16295
- Background
HSK-3486 is under investigation in clinical trial NCT04620031 (A Study Evaluating Sedation of Intravenous Administration of HSK3486 Injectable Emulsion in ICU Patients Undergoing Mechanical Ventilation).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for HSK-3486 (DB16295)
- Weight
- Average: 204.313
Monoisotopic: 204.151415264 - Chemical Formula
- C14H20O
- Synonyms
- Not Available
- External IDs
- HSK-3486
- HSK-3486, (R)-
- HSK3486
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- M3WGS532VY
- CAS number
- 1637741-58-2
- InChI Key
- BMEARIQHWSVDBS-SNVBAGLBSA-N
- InChI
- InChI=1S/C14H20O/c1-9(2)12-5-4-6-13(14(12)15)10(3)11-7-8-11/h4-6,9-11,15H,7-8H2,1-3H3/t10-/m1/s1
- IUPAC Name
- 2-[(1R)-1-cyclopropylethyl]-6-(propan-2-yl)phenol
- SMILES
- CC(C)C1=CC=CC([C@H](C)C2CC2)=C1O
References
- General References
- Not Available
- External Links
- ChemSpider
- 76794458
- ChEMBL
- CHEMBL4094894
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Anesthesia therapy 1 3 Completed Treatment Induction and Maintenance of General Anesthesia 1 3 Completed Treatment Induction of anesthesia therapy 1 3 Completed Treatment Sedation in Intensive Care Unit Patients 1 3 Completed Treatment Sedation or Anesthesia 2 3 Not Yet Recruiting Treatment General Anesthesia 2 2 Completed Treatment Colonoscopy 1 2 Completed Treatment Induction and Maintenance of General Anesthesia 1 2 Completed Treatment Induction of General Anesthesia 1 2 Completed Treatment Sedation 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0346 mg/mL ALOGPS logP 4.53 ALOGPS logP 4.43 ChemAxon logS -3.8 ALOGPS pKa (Strongest Acidic) 10.95 ChemAxon pKa (Strongest Basic) -5 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 1 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 20.23 Å2 ChemAxon Rotatable Bond Count 3 ChemAxon Refractivity 63.77 m3·mol-1 ChemAxon Polarizability 24.64 Å3 ChemAxon Number of Rings 2 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at December 15, 2020 18:18 / Updated at December 20, 2020 03:40