Ezurpimtrostat

DB16458InvestigationalSmall molecule

Ezurpimtrostat: Overview.

Mechanism: GNS561, a potent chloroquine analog, is a lysosomotropic small molecule. It induces lysosomal dysregulation which causes cell death and has anti-cancer properties specifically targeting intrahepatic cholangiocarcinoma.
Curator reviewed
Formula / weight: C₂₅H₃₁ClN₄ · 423.0 g/mol (avg)
Also known as: Chloroquine analog
Code names: GNS561

Resolves to

Compound

Structure

InChIKeyQVXSJSXAVQJXOV-UHFFFAOYSA-NSMILESCC(C)(C)NC1CCN(CC1)C1=CC(NCC2=CC=C(Cl)C=C2)=NC2=CC=CC=C12

Targets

What you can answer from here — as of July 08, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

5Clinical trialsPhase, status and sponsor resolved per trial

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Ezurpimtrostat, and which of those have an active Phase 3 trial?

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