Palmitoyl-protein thioesterase 1

BE0004538ProteinHumansPPT1

Has thioesterase activity against fatty acid thioesters with 14 -18 carbons, including palmitoyl-CoA, S-palmitoyl-N-acetylcysteamine, and palmitoylated proteins (PubMed:12855696, PubMed:26731412, PubMed:8816748). It is acted on by 4 drugs in DrugBank.

Gene name
PPT1
UniProtKB entry
P50897Swiss-Prot
Cellular location
Lysosome
Residues / weight
306 residues · 34,193 Da
Also known as
3.1.2.2 · 3.1.2.22 · CLN1 · Palmitoyl-protein hydrolase 1 · PPT

Resolves to

Protein
UniProtP50897UniProt namePPT1_HUMAN
Gene
HGNCHGNC:9325NCBI Gene5538GeneCardsPPT1
Pharmacology
KEGGhsa:5538
Structure
PDB3GRO
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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30GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Palmitoyl-protein thioesterase 1, how selective are they, and which programs against it are still in active trials?

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