TAK-418 free base

DB16939InvestigationalSmall molecule

TAK-418 free base: Overview.

Mechanism: Pharmacologically active on Lysine-specific histone demethylase 1A
Curator reviewed
Formula / weight: C₁₇H₂₄N₂O₂S · 320.45 g/mol (avg)
Also known as: 5-((1R,2R)-2-((Cyclopropylmethyl)amino)cyclopropyl)-N-(tetrahydro-2H-pyran-4-yl)thiophene-3-carboxamide
Code names: TAK-418

Resolves to

Compound

Structure

InChIKeyQZNGFWQWWSECMG-HUUCEWRRSA-NSMILESO=C(NC1CCOCC1)C1=CSC(=C1)[C@@H]1C[C@H]1NCC1CC1

Targets

What you can answer from here — as of September 13, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with TAK-418 free base, and which of those have an active Phase 3 trial?

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