Lysine-specific histone demethylase 1A

BE0010091ProteinHumansKDM1A

Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). It is acted on by 10 drugs in DrugBank.

Gene name
KDM1A
UniProtKB entry
O60341Swiss-Prot
Cellular location
Nucleus
Residues / weight
852 residues · 92,902 Da
Also known as
[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A · 1.14.11.- · 1.14.11.65 · 1.14.99.66 · AOF2

Resolves to

Protein
UniProtO60341UniProt nameKDM1A_HUMAN
Gene
HGNCHGNC:29079NCBI Gene23028GeneCardsKDM1A
Pharmacology
IUPHAR/GtoPdb2669KEGGhsa:23028
Structure
PDB2COMPDB2DW4PDB2EJR
Drugs

What you can answer from here — as of October 04, 2021

10DrugsApproved to experimental, with action, bond type and pharmacological action
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26GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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74+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lysine-specific histone demethylase 1A, how selective are they, and which programs against it are still in active trials?

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