MRK-003

DB17015ExperimentalSmall molecule

MRK-003 is a potent and selective γ-secretase inhibitor developed by Merck. It is the preclinical analog of MK-0752, a drug in clinical development.

Mechanism: Pharmacologically active on Presenilin-1
Curator reviewed
Formula / weight: C₂₅H₃₁F₆N₃O₂S · 551.59 g/mol (avg)
Also known as: (1'R,4R)-2-(2,2,2-trifluoroethyl)-5'-[(E)-3-[4-(trifluoromethyl)piperidin-1-yl]prop-1-enyl]spiro[1,2,5-thiadiazolidine-4,13'-tricyclo[8.2.1.03,8]trideca-3(8),4,6-triene] 1,1-dioxide
Code names: MRK-003

Resolves to

Compound

Structure

InChIKeyNKHUILHBYOOZDF-NCOIWELASA-NSMILES[H][C@]12CC[C@]([H])(CC3=CC(\C=C\CN4CCC(CC4)C(F)(F)F)=CC=C3C1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1

Targets

What you can answer from here — as of July 08, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with MRK-003, and which of those have an active Phase 3 trial?

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