Presenilin-1

BE0010960ProteinHumansPSEN1

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632,... It is acted on by 15 drugs in DrugBank.

Gene name
PSEN1
UniProtKB entry
P49768Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
467 residues · 52,667 Da
Also known as
3.4.23.- · AD3 · Protein S182 · PS-1 · PS1

Resolves to

Protein
UniProtP49768UniProt namePSN1_HUMAN
Gene
HGNCHGNC:9508NCBI Gene5663GeneCardsPSEN1
Pharmacology
IUPHAR/GtoPdb2402KEGGhsa:5663
Structure
PDB2KR6PDB4UISPDB5A63
Drugs

What you can answer from here — as of December 02, 2023

15DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
83GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
26+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Presenilin-1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In