Nutlin-3

DB17039ExperimentalSmall molecule

Nutlin-3 is a small molecule inhibitor that targets p53-Mdm2 interaction.

Chemical structure of Nutlin-3
Formula / weight
C30H30Cl2N4O4 · 581.49 g/mol (avg)
Also known as
2-piperazinone, 4-(((4r,5s)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-(4-methoxy-2-(1-methylethoxy)phenyl)-1h-imidazol-1-yl)carbonyl)-, rel-
Code names
NSC-732664

Resolves to

Compound
UNIIL7C92IOE65CAS548472-68-0ChEMBLCHEMBL191334ChEBI95096
Structure
InChIKeyBDUHCSBCVGXTJM-WUFINQPMSA-NSMILESCOC1=CC=C(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)C2=CC=C(Cl)C=C2)C2=CC=C(Cl)C=C2)C(OC(C)C)=C1
Targets
P04637TP53

What you can answer from here — as of September 20, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
4+ReferencesStructured and connected to the statements they support
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