Cellular tumor antigen p53

BE0003380ProteinHumansTP53

Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238,... It is acted on by 24 drugs in DrugBank.

Gene name
TP53
UniProtKB entry
P04637Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
393 residues · 43,653 Da
Also known as
Antigen NY-CO-13 · P53 · Phosphoprotein p53 · Tumor suppressor p53

Resolves to

Protein
UniProtP04637UniProt nameP53_HUMAN
Gene
HGNCHGNC:11998NCBI Gene7157GeneCardsTP53
Pharmacology
KEGGhsa:7157
Structure
PDB1A1UPDB1AIEPDB1C26
Drugs

What you can answer from here — as of September 07, 2019

24DrugsApproved to experimental, with action, bond type and pharmacological action
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198Clinical trialsTrials of drugs acting on it, by phase and status
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62GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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234+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cellular tumor antigen p53, how selective are they, and which programs against it are still in active trials?

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