NAV

SRT-1720

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
SRT-1720
DrugBank Accession Number
DB17057
Background

SRT-1720 is an activator of NAD(+)-dependent histone deacetylase SIRT1.1

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 469.57
Monoisotopic: 469.168479563
Chemical Formula
C25H23N7OS
Synonyms
  • 2-quinoxalinecarboxamide, n-(2-(3-(1-piperazinylmethyl)imidazo(2,1-b)thiazol-6-yl)phenyl)-
  • N-(2-(3-(1-piperazinylmethyl)imidazo(2,1-b)thiazol-6-yl)phenyl)-2-quinoxalinecarboxamide
External IDs
  • SRT-1720
  • SRT1720
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
DX3FHY76FZ
CAS number
925434-55-5
InChI Key
IASPBORHOMBZMY-UHFFFAOYSA-N
InChI
InChI=1S/C25H23N7OS/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31/h1-8,13,15-16,26H,9-12,14H2,(H,29,33)
IUPAC Name
N-(2-{3-[(piperazin-1-yl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl}phenyl)quinoxaline-2-carboxamide
SMILES
O=C(NC1=C(C=CC=C1)C1=CN2C(CN3CCNCC3)=CSC2=N1)C1=CN=C2C=CC=CC2=N1

References

General References
  1. Fan H, Yang HC, You L, Wang YY, He WJ, Hao CM: The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury. Kidney Int. 2013 Mar;83(3):404-13. doi: 10.1038/ki.2012.394. Epub 2013 Jan 9. [Article]
Human Metabolome Database
HMDB0247660
ChemSpider
20581461
BindingDB
50228363
ChEMBL
CHEMBL257991
ZINC
ZINC000029043612
PDBe Ligand
SR7
Wikipedia
SRT-1720
PDB Entries
4bn5

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0318 mg/mLALOGPS
logP2.62ALOGPS
logP2.96Chemaxon
logS-4.2ALOGPS
pKa (Strongest Acidic)13.69Chemaxon
pKa (Strongest Basic)9.22Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area87.45 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity144.01 m3·mol-1Chemaxon
Polarizability50.92 Å3Chemaxon
Number of Rings6Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at October 11, 2022 18:58 / Updated at December 01, 2022 11:34