NAD-dependent protein deacetylase sirtuin-1

BE0002461ProteinHumansSIRT1

NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491,... It is acted on by 10 drugs in DrugBank.

Gene name
SIRT1
UniProtKB entry
Q96EB6Swiss-Prot
Cellular location
Nucleus, PML body
Residues / weight
747 residues · 81,680 Da
Also known as
2.3.1.286 · hSIR2 · hSIRT1 · NAD-dependent protein deacylase sirtuin-1 · Regulatory protein SIR2 homolog 1

Resolves to

Protein
UniProtQ96EB6UniProt nameSIR1_HUMAN
Gene
HGNCHGNC:14929NCBI Gene23411GeneCardsSIRT1
Pharmacology
IUPHAR/GtoPdb2707KEGGhsa:23411
Structure
PDB4I5IPDB4IF6PDB4IG9
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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84GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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121+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NAD-dependent protein deacetylase sirtuin-1, how selective are they, and which programs against it are still in active trials?

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