APTO-253

DB17143InvestigationalSmall molecule

APTO-253: Overview.

Chemical structure of APTO-253
Formula / weight
C22H14FN5 · 367.387 g/mol (avg)
Also known as
1h-imidazo(4,5-f)(1,10)phenanthroline, 2-(5-fluoro-2-methyl-1h-indol-3-yl)- · 2-(5-fluoro-2-methyl-1h-indol-3-yl)-1h-imidazo(4,5-f)(1,10)phenanthroline · 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10] phenanthroline · Lor-253(former code) · Lt-253(former code)
Code names
APTO-253 · LOR-253 · LT-253

Resolves to

Compound
UNIIWB59MRW00UCAS916151-99-0ChEMBLCHEMBL4297261
Structure
InChIKeyNIRXBXIPHUTNNI-UHFFFAOYSA-NSMILESCC1=C(C2=NC3=C(N2)C2=CC=CN=C2C2=C3C=CC=N2)C2=C(N1)C=CC(F)=C2
Targets
O43474KLF4

What you can answer from here — as of April 23, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
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2Clinical trialsPhase, status and sponsor resolved per trial
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1+ReferenceStructured and connected to the statements they support
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Which drugs share a target with APTO-253, and which of those have an active Phase 3 trial?

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