Tapotoclax

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DB17166InvestigationalSmall molecule

Tapotoclax: Overview.

Formula / weight: C₃₃H₄₁ClN₂O₅S · 613.21 g/mol (avg)
Also known as: MCL-1 inhibitor AMG 176 · MCL-1 inhibitor AMG-176
Code names: AMG-176

Resolves to

Compound

UNII97W7N9T08GCAS1883727-34-1ChEMBLCHEMBL4446378

Structure

InChIKeyJQNINBDKGLWYMU-GEAQBIRJSA-NSMILESCO[C@H]1\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C2=CC3=C(OC[C@]4(CCCC5=C4C=CC(Cl)=C5)CN3C[C@@H]3CC[C@@H]13)C=C2

Targets

Q07820MCL1

What you can answer from here — as of April 23, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Tapotoclax, and which of those have an active Phase 3 trial?

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