Induced myeloid leukemia cell differentiation protein Mcl-1

BE0003511ProteinHumansMCL1

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. It is acted on by 13 drugs in DrugBank.

Gene name
MCL1
UniProtKB entry
Q07820Swiss-Prot
Cellular location
Membrane
Residues / weight
350 residues · 37,337 Da
Also known as
Bcl-2-like protein 3 · Bcl-2-related protein EAT/mcl1 · Bcl2-L-3 · BCL2L3 · mcl1/EAT

Resolves to

Protein
UniProtQ07820UniProt nameMCL1_HUMAN
Gene
HGNCHGNC:6943NCBI Gene4170GeneCardsMCL1
Pharmacology
IUPHAR/GtoPdb2847KEGGhsa:4170
Structure
PDB2KBWPDB2MHSPDB2NL9
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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16Clinical trialsTrials of drugs acting on it, by phase and status
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18GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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50+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Induced myeloid leukemia cell differentiation protein Mcl-1, how selective are they, and which programs against it are still in active trials?

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