Lipotecan

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DB17385InvestigationalSmall molecule

Lipotecan: Overview.

Mechanism: Pharmacologically active on DNA topoisomerase 1
Curator reviewed
Formula / weight: C₃₉H₃₀N₈O₁₅ · 850.71 g/mol (avg)
Also known as: Lipothecan free base · Propanoic acid, 2-(((2,4,5,7-tetranitro-9h-fluoren-9-ylidene)amino)oxy)-, (4s)-10-((dimethylamino)methyl)-4-ethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-4-yl ester
Code names: TLC-388

Resolves to

Compound

UNIID47234N30NCAS1432468-79-5ChEMBLCHEMBL4594352

Structure

InChIKeyJCCCLGDYMMTBPM-HXDHBHDHSA-NSMILES

CC[C@@]1(OC(=O)C(C)ON=C2C3=C(C4=C2C=C(C=C4[N+]([O-])=O)[N+]([O-])=O)C(=CC(=C3)[N+]([O-])=O)[N+]([O-])=O)C(=O)OCC2=C1C=C1N(CC3=C1N=C1C=CC(O)=C(CN(C)C)C1=C3)C2=O

Targets

P11387TOP1

What you can answer from here — as of July 17, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

6Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Lipotecan, and which of those have an active Phase 3 trial?

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