DNA topoisomerase 1

BE0000971ProteinHumansTOP1

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. It is acted on by 56 drugs in DrugBank.

Gene name
TOP1
UniProtKB entry
P11387Swiss-Prot
Cellular location
Nucleus, nucleolus
Residues / weight
765 residues · 90,725 Da
Also known as
5.6.2.1 · DNA topoisomerase I

Resolves to

Protein
UniProtP11387UniProt nameTOP1_HUMAN
Gene
HGNCHGNC:11986NCBI Gene7150GenBank339806GeneCardsTOP1
Pharmacology
KEGGhsa:7150
Structure
PDB1A31PDB1A35PDB1A36
Drugs

What you can answer from here — as of September 07, 2019

56DrugsApproved to experimental, with action, bond type and pharmacological action
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44Clinical trialsTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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181+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA topoisomerase 1, how selective are they, and which programs against it are still in active trials?

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