NAV

Zanzalintinib

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Zanzalintinib
DrugBank Accession Number
DB17525
Background

Not Available

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 528.54
Monoisotopic: 528.180898084
Chemical Formula
C29H25FN4O5
Synonyms
  • XL092
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
KC2JC2ZA04
CAS number
2367004-54-2
InChI Key
JSPCKALGNNVYOO-UHFFFAOYSA-N
InChI
InChI=1S/C29H25FN4O5/c1-31-26(35)22-15-21-23(16-25(22)38-2)32-14-11-24(21)39-20-9-7-19(8-10-20)34-28(37)29(12-13-29)27(36)33-18-5-3-17(30)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,35)(H,33,36)(H,34,37)
IUPAC Name
N1-(4-fluorophenyl)-N'1-(4-{[7-methoxy-6-(methylcarbamoyl)quinolin-4-yl]oxy}phenyl)cyclopropane-1,1-dicarboxamide
SMILES
CNC(=O)C1=CC2=C(OC3=CC=C(NC(=O)C4(CC4)C(=O)NC4=CC=C(F)C=C4)C=C3)C=CN=C2C=C1OC

References

General References
Not Available
ChemSpider
114641993

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3RecruitingTreatmentColorectal Cancer1
3RecruitingTreatmentNon Clear Cell Renal Cell Carcinoma (nccRCC)1
2, 3RecruitingTreatmentSquamous Cell Carcinoma of the Head and Neck (SCCHN)1
1Active Not RecruitingTreatmentColorectal Cancer / Hormone Receptor Positive Breast Carcinoma / Malignant Neoplasm / Metastatic Castration-Resistant Prostate Cancer (mCRPC) / Renal Cell Carcinoma (RCC)1
1RecruitingTreatmentColorectal Cancer / Hepatocellular Carcinoma / Metastatic Castration-Resistant Prostate Cancer (mCRPC) / Non-Small Cell Lung Cancer (NSCLC) / Renal Cell Carcinoma (RCC) / Solid Tumors / Squamous Cell Carcinoma of the Head and Neck (SCCHN) / Urothelial Carcinoma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0031 mg/mLALOGPS
logP3.67ALOGPS
logP3.89Chemaxon
logS-5.2ALOGPS
pKa (Strongest Acidic)13.28Chemaxon
pKa (Strongest Basic)5.4Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area118.65 Å2Chemaxon
Rotatable Bond Count8Chemaxon
Refractivity143.63 m3·mol-1Chemaxon
Polarizability53.24 Å3Chemaxon
Number of Rings5Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at February 14, 2023 20:35 / Updated at February 15, 2023 07:40