Zanzalintinib
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Zanzalintinib
- DrugBank Accession Number
- DB17525
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 528.54
Monoisotopic: 528.180898084 - Chemical Formula
- C29H25FN4O5
- Synonyms
- XL092
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- KC2JC2ZA04
- CAS number
- 2367004-54-2
- InChI Key
- JSPCKALGNNVYOO-UHFFFAOYSA-N
- InChI
- InChI=1S/C29H25FN4O5/c1-31-26(35)22-15-21-23(16-25(22)38-2)32-14-11-24(21)39-20-9-7-19(8-10-20)34-28(37)29(12-13-29)27(36)33-18-5-3-17(30)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,35)(H,33,36)(H,34,37)
- IUPAC Name
- N1-(4-fluorophenyl)-N'1-(4-{[7-methoxy-6-(methylcarbamoyl)quinolin-4-yl]oxy}phenyl)cyclopropane-1,1-dicarboxamide
- SMILES
- CNC(=O)C1=CC2=C(OC3=CC=C(NC(=O)C4(CC4)C(=O)NC4=CC=C(F)C=C4)C=C3)C=CN=C2C=C1OC
References
- General References
- Not Available
- External Links
- ChemSpider
- 114641993
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Recruiting Treatment Colorectal Cancer 1 3 Recruiting Treatment Non Clear Cell Renal Cell Carcinoma (nccRCC) 1 2, 3 Recruiting Treatment Squamous Cell Carcinoma of the Head and Neck (SCCHN) 1 1 Active Not Recruiting Treatment Colorectal Cancer / Hormone Receptor Positive Breast Carcinoma / Malignant Neoplasm / Metastatic Castration-Resistant Prostate Cancer (mCRPC) / Renal Cell Carcinoma (RCC) 1 1 Recruiting Treatment Colorectal Cancer / Hepatocellular Carcinoma / Metastatic Castration-Resistant Prostate Cancer (mCRPC) / Non-Small Cell Lung Cancer (NSCLC) / Renal Cell Carcinoma (RCC) / Solid Tumors / Squamous Cell Carcinoma of the Head and Neck (SCCHN) / Urothelial Carcinoma 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0031 mg/mL ALOGPS logP 3.67 ALOGPS logP 3.89 Chemaxon logS -5.2 ALOGPS pKa (Strongest Acidic) 13.28 Chemaxon pKa (Strongest Basic) 5.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 118.65 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 143.63 m3·mol-1 Chemaxon Polarizability 53.24 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at February 14, 2023 20:35 / Updated at February 15, 2023 07:40