Hepatocyte growth factor receptor

BE0000915ProteinHumansMET

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. It is acted on by 59 drugs in DrugBank.

Gene name
MET
UniProtKB entry
P08581Swiss-Prot
Cellular location
Membrane
Residues / weight
1,390 residues · 155,540 Da
Also known as
2.7.10.1 · HGF receptor · HGF/SF receptor · Proto-oncogene c-Met · Scatter factor receptor

Resolves to

Protein
UniProtP08581UniProt nameMET_HUMAN
Gene
HGNCHGNC:7029NCBI Gene4233GenBank307196GeneCardsMET
Pharmacology
IUPHAR/GtoPdb1815KEGGhsa:4233
Structure
PDB1FYRPDB1R0PPDB1R1W
Drugs

What you can answer from here — as of September 07, 2019

59DrugsApproved to experimental, with action, bond type and pharmacological action
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86Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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222+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hepatocyte growth factor receptor, how selective are they, and which programs against it are still in active trials?

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